Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Molecular characterization of colorectal cancer related peritoneal metastatic disease [scRNA-seq]

ABSTRACT: Molecular characterization of colorectal cancer related peritoneal metastatic disease [scRNA-seq]

PROVIDER: PRJNA762334 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Molecular characterization of colorectal cancer-related peritoneal metastatic disease

Project description:Molecular characterization of colorectal cancer-related peritoneal metastatic disease

| PRJNA762330 | ENA

Molecular characterization of colorectal cancer-related peritoneal metastatic disease [RNA-seq]

Project description:Molecular characterization of colorectal cancer-related peritoneal metastatic disease [RNA-seq]

| PRJNA759609 | ENA

Molecular characterization of colorectal cancer related peritoneal metastatic disease [scRNA-seq]

Project description:We present acomprehensive molecular characterization of a cohort of 5 patients with peritoneal metastasis

2022-06-30 | GSE183916 | GEO

Molecular characterization of colorectal cancer-related peritoneal metastatic disease [RNA-seq]

Project description:We present a comprehensive molecular characterization of a cohort of 52 patients with peritoneal metastasis

2022-06-01 | GSE183202 | GEO

Proteomic characterization of metastatic colorectal cancer

Project description:To characterize metastatic progression of colorectal cancer, we performed mass spectrometry-based proteome analysis using large clinical cohort samples.

2024-01-16 | PXD031705 | Pride

Molecular characterization of colorectal cancer related peritoneal metastatic disease.

Project description:A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease outcome. To improve care for this patient group, a better understanding of the molecular characteristics of CRC-PM is required. Here we present a comprehensive molecular characterization of a cohort of 52 patients. This reveals that CRC-PM represent a distinct CRC molecular subtype, CMS4, but can be further divided in three separate categories, each presenting with unique features. We uncover that the CMS4-associated structural protein Moesin plays a key role in peritoneal dissemination. Finally, we define specific evolutionary features of CRC-PM which indicate that polyclonal metastatic seeding underlies these lesions. Together our results suggest that CRC-PM should be perceived as a distinct disease entity.

| S-EPMC9352687 | biostudies-literature

Molecular characterization of colorectal cancer-related peritoneal metastatic disease

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-06-01 | GSE183917 | GEO

Proteogenomic characterization of metastatic colorectal cancer with its primary origin

Project description:To characterize metastatic progression of colorectal cancer, we performed mass spectromery-based proteome analysis using clinical samples.

2024-01-16 | PXD034575 | Pride

Orthotopic CRC organoid transplantation in mice: A novel model for the study and treatment of peritoneal carcinomatosis [TIL scRNA-Seq]

Project description:Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major cause of death in UICC stage IV CRC patients. Insights into differential site-specific reconstitution of tumor cells and the corresponding tumor microenvironment are still missing. Here, we analysed the transcriptome of single cells derived from murine multivisceral CRC and gave insight into the inter-metastatic cellular heterogeneity regarding tumor epithelium, stroma and immune cells. Interestingly, we found an intercellular site-specific network of cancer associated fibroblasts and tumor epithelium during peritoneal metastasis as well as an autologous feed-forward loop in cancer stem cells. We furthermore deciphered a metastatic dysfunctional adaptive immunity by a loss of B cell dependent antigen presentation and consecutive effector cell exhaustion. Consequently, we demonstrate the high human-mimicking potential of this murine metastatic CRC model and provide a valid tool for future site-specific preclinical drug testing.

2024-01-10 | GSE220175 | GEO

Orthotopic CRC organoid transplantation in mice: A novel model for the study and treatment of peritoneal carcinomatosis [Whole-tumor scRNA-Seq]

2024-01-10 | GSE220506 | GEO