Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide transcriptome analysis of human iPSC-derived healthy control vs schizophrenia developmental glutamatergic neurons.

ABSTRACT: Genome-wide transcriptome analysis of human iPSC-derived healthy control vs schizophrenia developmental glutamatergic neurons.

PROVIDER: PRJNA763187 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15893390_1.fastq.gz	Fastqsanger.gz
	SRR15893390_2.fastq.gz	Fastqsanger.gz
	SRR15893391_1.fastq.gz	Fastqsanger.gz
	SRR15893391_2.fastq.gz	Fastqsanger.gz
	SRR15893392_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Genome-wide transcriptome analysis of human iPSC-derived healthy control vs schizophrenia developmental glutamatergic neurons.

Project description:We report changes in gene expression in schizophrenia developmental glutamatergic neurons by genome-wide transcriptome analysis.

2022-12-31 | GSE184102 | GEO

Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development

Project description:Genome binding/occupancy profiling was carried out by high throughput sequencing in human developmental cortical interneurons and developmental glutamatergic neurons derived from healthy control vs schizophrenia iPSCs

2022-12-21 | GSE184165 | GEO

Common schizophrenia risk variants are implicated in the function of glutamatergic neurons

Project description:The epigenome of human brain cells encompasses key information in understanding brain function in both healthy and diseased states. To further explore this, we used ATAC-seq to profile chromatin structure in four distinct populations of cells (glutamatergic neurons, GABAergic neurons, oligodendrocytes, and microglia/astrocytes), from three different regions of the brain. Chromatin accessibility was found to vary vastly by cell type and, more moderately, by brain region, with glutamatergic neurons showing the greatest regional variability. Transcription factor footprinting pointed to cell-specific transcriptional regulators and inferred cell-specific regulation of protein coding genes, long intergenic noncoding RNAs, and microRNAs. In vivo transgenic mouse experiments validated the cell type specificity of a number of human-derived regulatory sequences. Open chromatin regions in glutamatergic neurons were enriched for neuropsychiatric risk variants, particularly those associated with schizophrenia. Combining differential chromatin accessibility analysis using ATAC-seq data from bulk tissue increased our statistical power to confirm glutamatergic neurons as the cell type most affected in schizophrenia. Jointly, these findings illustrate the utility of studying the cell type specific epigenome in complex tissues such as the human brain and implicate an association among chromatin accessibility in glutamatergic neurons and genetic risk for schizophrenia.

2020-08-20 | GSE143666 | GEO

A Co-Culture Model of Dopaminergic and Glutamatergic Neurons Derived from Patients with Idiopathic Schizophrenia reveals a Hypodopaminergic Phenotype

Project description:To identify morphological and functional phenotypes relevant for SCZ, we generated iPSC-derived dopaminergic neurons from three healthy controls and four patient with schizophrenia. We then performed gene expression profiling analysis using data obtained from RNA-seq of four schizophrenia patients and three controls to determine significantly deregulated genes in schizophrenia dopaminergic neurons.

2024-08-27 | GSE275064 | GEO

Common schizophrenia risk variants are implicated in the function of glutamatergic neurons

Project description:Common schizophrenia risk variants are implicated in the function of glutamatergic neurons

| PRJNA601202 | ENA

Pilot transcriptome analysis of human iPSC-derived healthy control vs. schizophrenia cortical interneurons

Project description:We report specific changes in schizophrenia developmental interneurons by genome-wide transcriptome analysis.

2019-04-25 | GSE125805 | GEO

Genome-wide transcriptional analysis of human iPSC-derived healthy control vs. schizophrenia cortical interneurons.

Project description:We report specific changes in schizophrenia developmental interneurons by genome-wide transcriptome analysis.

2019-04-25 | GSE125999 | GEO

Genome-wide transcriptional analysis of human iPSC-derived healthy control vs. schizophrenia cortical interneurons

Project description:We report specific changes in schizophrenia developmental interneurons by genome-wide transcriptome analysis.

2018-10-18 | GSE121376 | GEO

Pilot transcriptome analysis of human iPSC-derived healthy control vs. schizophrenia cortical interneurons

Project description:Pilot transcriptome analysis of human iPSC-derived healthy control vs. schizophrenia cortical interneurons

| PRJNA517592 | ENA

Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development

Project description:Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development

| PRJNA763492 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data