Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human vaginal metagenome

ABSTRACT: Cervicovaginal microbiome of HPV infected Mexican women

PROVIDER: PRJNA763215 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR16320226_1.fastq.gz	Fastqsanger.gz
	SRR16320226_2.fastq.gz	Fastqsanger.gz
	SRR16320227_1.fastq.gz	Fastqsanger.gz
	SRR16320227_2.fastq.gz	Fastqsanger.gz
	SRR16320228_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 126

Similar Datasets

Results of the phase 1, randomized, placebo-controlled first-in-human trial of griffithsin formulated in a carrageenan vaginal gel

Project description:Griffithsin (GRFT) is an anti-viral lectin with potent anti-HIV activity. GRFT’s preclinical safety, lack of systemic absorption after topical administration, and lack of cross-resistance with existing products prompted its development for topical HIV pre-exposure prophylaxis. We evaluated safety, pharmacokinetics and pharmacodynamics of PC-6500 (0.1% GRFT in a carrageenan (CG) gel) in healthy, HIV-negative, non-pregnant women following once daily vaginal gel administration for 14 days. No significant adverse events, histopathological changes in cervico-vaginal mucosa, or anti-drug (GRFT) antibodies were detected. No cervicovaginal proinflammatory responses and no changes in the ectocervical transcriptome were evident. Vaginal microbiome remained largely unchanged. Reduced abundance of vaginosis-associated bacteria and decreased levels of proinflammatory chemokines (CXCL8 and CCL20) were observed. GRFT was not detected in plasma. GRFT and GRFT/CG in CVLs dose-dependently inhibited HIV and HPV, respectively, in vitro. The data suggest GRFT/CG is a promising on-demand multipurpose prevention product that warrants further investigation.

2021-10-04 | GSE141478 | GEO

human vaginal metagenome

Project description:Cervicovaginal Microbiome Changes as Predictors of Preterm Birth

| PRJNA1177804 | ENA

human vaginal metagenome

Project description:Vaginal microbiome of Canadian women

| PRJNA278895 | ENA

Human vaginal metagenome

Project description:Vaginal microbiome of South African women

| PRJNA767784 | ENA

human vaginal metagenome

Project description:Vaginal microbiome of healthy pregnant women