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Environmental sensing by fibroblasts regulates tissue composition

ABSTRACT: Environmental sensing by fibroblasts regulates tissue composition

PROVIDER: PRJNA766220 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16071300_1.fastq.gz	Fastqsanger.gz
	SRR16071300_2.fastq.gz	Fastqsanger.gz
	SRR16071301_1.fastq.gz	Fastqsanger.gz
	SRR16071301_2.fastq.gz	Fastqsanger.gz
	SRR16071302_1.fastq.gz	Fastqsanger.gz

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Environmental sensing by fibroblasts regulates tissue composition

Project description:Diverse cell types comprise animal tissues. However, the mechanisms controlling the number of each cell type within tissue compartments remain poorly understood. Here, we reported that different cell types utilize distinct strategies to control population numbers. Proliferation of fibroblasts, stromal cells important for tissue integrity, is limited by space availability. In contrast, proliferation of macrophages, innate immune cells involved in defense, repair, and homeostasis, is constrained by growth factor availability. Examination of density-dependent gene expression in fibroblasts revealed that Hippo and Tgf-b signaling are both regulated by cell density. We found YAP1, the transcriptional activator of the Hippo signaling pathway, directly regulate expression of Csf1, the lineage-specific growth factor for macrophages, through binding of YAP1 to a conserved enhancer of Csf1 that is specifically active in fibroblasts. Activation of YAP1 in fibroblasts elevates Csf1 expression, and is sufficient to increase the number of macrophages at steady state. Our data also suggest that expression programs in fibroblasts that change with density may result from sensing of mechanical pressure through actin-dependent mechanisms. Altogether, we demonstrate that two different modes of population control are connected and coordinated to regulate cell numbers of distinct cell types. Sensing of the tissue environment may serve as a general strategy to control tissue composition.

2022-07-21 | GSE184774 | GEO

Microenvironmental Sensing by Fibroblasts Controls Macrophage Population Size

Project description:Animal tissues are comprised of diverse cell types. However, the mechanisms controlling the number of each cell type within tissue compartments remain poorly understood. Here, we report that different cell types utilize distinct strategies to control population numbers. Proliferation of fibroblasts, stromal cells important for tissue integrity, is limited by space availability. In contrast, proliferation of macrophages, innate immune cells involved in defense, repair, and homeostasis, is constrained by growth factor availability. Examination of density-dependent gene expression in fibroblasts revealed that Hippo and TGF- target genes are both regulated by cell density. We found YAP1, the transcriptional co-activator of the Hippo signaling pathway, directly regulates expression of Csf1, the lineage-specific growth factor for macrophages, through an enhancer of Csf1 that is specifically active in fibroblasts. Activation of YAP1 in fibroblasts elevates Csf1 expression and is sufficient to increase the number of macrophages at steady state. Our data also suggest that expression programs in fibroblasts that change with density may result from sensing of mechanical force through actin-dependent mechanisms. Altogether, we demonstrate that two different modes of population control are connected and coordinated to regulate cell numbers of distinct cell types. Sensing of the tissue environment may serve as a general strategy to control tissue composition.

2022-06-09 | GSE205381 | GEO

Project description:Environmental sensing by fibroblasts regulates tissue composition

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Plastid signaling triggers HDA6-mediated epigenetic programs during environmental sensing in plants [RNA-seq]

Project description:Plants adapt to environmental changes by adjusting growth and defense, and the role of epigenetic modifications in this process is unclear. Sensing and adjusting to environmental changes are more important in certain tissues such as epidermis, vasculature, meristem, and reproductive tissues. These tissues possess sensory plastids that are specialized in environmental sensing. We show perturbation of four sensory plastid proteins MSH1, PPD3, CUE1, and SAL1 induce gene expression and DNA methylation changes targeted to networks associated to environmental sensing, with significant overlap with hda6-induced CHG hypermethylated genes at 12-hr daylength. At 16-hr daylength, hda6 loses CHG hypermethylation in gene body, and sensory plastid mutants have weaker phenotypes and DNA methylation- and gene expression- associated gene networks. We show daylength-responsive epistatic interaction between sensory plastid mutants with hda6. We also show that hda6 mutation confers daylength memory and, with msh1, enhanced tolerance to heat stress and biotic stress. These results suggest that HDA6 mediates programmed adjustments in plant phenotype triggered by sensory plastid-to-nucleus retrograde signaling in response to daylength and environmental cues.

2024-06-20 | GSE270059 | GEO

Plastid signaling triggers HDA6-mediated epigenetic programs during environmental sensing in plants [Bisulfite-seq]

2024-06-20 | GSE270032 | GEO

Microenvironmental Sensing by Fibroblasts Controls Macrophage Population Size

Project description:Microenvironmental Sensing by Fibroblasts Controls Macrophage Population Size

| PRJNA844914 | ENA

MYCT1 Controls Environmental Sensing in human Hematopoietic Stem Cells.

Project description:MYCT1 Controls Environmental Sensing in human Hematopoietic Stem Cells.

| PRJNA971727 | ENA

MYCT1 Controls Environmental Sensing in human Hematopoietic Stem Cells [RNA-seq]

Project description:MYCT1 Controls Environmental Sensing in human Hematopoietic Stem Cells [RNA-seq]

| PRJNA971732 | ENA

MYCT1 Controls Environmental Sensing in human Hematopoietic Stem Cells [scRNA-seq]

Project description:MYCT1 Controls Environmental Sensing in human Hematopoietic Stem Cells [scRNA-seq]

| PRJNA971733 | ENA

Transcription profiling of cod to determine whether gene expression profiles would reflect environmental levels and composition of pollutants in two saltwater recipients, Sarfjorden and Store Lungegardsvann

Project description:In the present study we aimed to develop a custom made cDNA microarray, the CodStress array, for Atlantic cod to be used as a diagnostic tool in environmental monitoring of polluted waters. We wanted to investigate if the gene expression profiles would reflect environmental levels and composition of pollutants in two saltwater recipients, S?rfjorden and Store Lungeg?rdsvann.

2009-06-01 | E-BASE-11 | biostudies-arrayexpress

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