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Gene expression profiling of trophoblastic organoid from the placental villi of intrauterine and tubal ectopic pregnancies

ABSTRACT: Gene expression profiling of trophoblastic organoid from the placental villi of intrauterine and tubal ectopic pregnancies

PROVIDER: PRJNA767678 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16133636_1.fastq.gz	Fastqsanger.gz
	SRR16133636_2.fastq.gz	Fastqsanger.gz
	SRR16133637_1.fastq.gz	Fastqsanger.gz
	SRR16133637_2.fastq.gz	Fastqsanger.gz
	SRR16133638_1.fastq.gz	Fastqsanger.gz

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Gene expression profiling of placental villi from intrauterine and tubal ectopic pregnancies

2022-12-10 | GSE210031 | GEO

Gene expression profiling of trophoblastic organoid from the placental villi of intrauterine and tubal ectopic pregnancies

Project description:The tubal ectopic pregnancy (TEP) is a severe pregnancy complication accounted for 10-15% pregnancy-related deaths owing to the implantation and growth of embryos in fallopian tubes. Placental villi from TEP exhibit significant difference compared with that from intrauterine pregnancy (IP) in total volumes, trophoblast differentiation and intravillous vascularization. To investigate the difference in expression profiles of placental villi from IP and TEP, placental villi were collected from each phenotype, separated from maternal tissues and analyzed by high-throughput sequencing. generated a mouse model in which p53 is activated in neural crest cells due to the expression of a mutant p53 protein (p53-25,26) that can bind to and stabilize wild-type p53. Here, we performed gene expression profiling on neural crest cells isolated from these embryos, to identify the transcriptional response to p53 activation during embryogenesis.

2024-09-02 | GSE185119 | GEO

Gene expression profiling of placental villi from intrauterine and tubal ectopic pregnancies

Project description:Gene expression profiling of placental villi from intrauterine and tubal ectopic pregnancies

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Endothelial cell response to trophoblastic debris

2016-08-21 | GSE69996 | GEO

Molecular expression in endometrial biopsies of non-viable ectopic and intrauterine pregnancies.

Project description:Ectopic pregnancy is the leading cause of morbidity and mortality among women in the first trimester. A reliable diagnostic test for the detection of ectopic pregnancy in cases of non-viable pregnancy of unknown location (NV-PUL) is needed. The objective of the current study is to prospectively validate our previous findings of a 12-cilia gene classifier for the identification of ectopic pregnancy. Molecular interrogation is performed to define differences in molecular expression profiles in ectopic and abnormal intrauterine pregnancies. These samples come from a prospective cohort study comparing transcriptome profiles from women with ectopic pregnancy (ECT) or non-viable intrauterine pregnancy (NV-IUP). Samples were analyzed with the Affymetrix Human Gene 2.0 ST Array.

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Endothelial cell response to trophoblastic debris

Project description:The human placenta is covered by a single multinucleated fetal cell, the syncytiotrophoblast, which is bathed in maternal blood. During all pregnancies, membrane enclosed extracellular vesicles derived from the syncytiotrophoblast are extruded into the maternal blood.The large size of these extracellular vesicles (diameter larger than 10Âµm) is referred to as trophoblastic debris in this study. We have shown in the past that endothleial cells are involved in clearence of this trophoblastic debris and induction of immune tolerence by trophoblastic debris.This study aimed to characterise the transcriptional changes that occur in human vascular endothelial cells following exposure to trophoblastic debris from normal first trimester placentae. Microarrays were used to probe transcriptomic changes 2 and 21 hours after exposure of endothelial cells (Human microvascular endothelial cell line,HMEC-1) to trophoblastic debris from normal first trimester placentae Trophoblastic debris were isolated by low speed centrifugation from three individual first trimester human placentae (three biological replicates). The protein content in trophoblastic debris was measured by BCA assay. HMEC-1 was co-cultured with trophoblastic debris (60ug/ml total debris protein contents) for either 2 or 21 hours before RNA extraction. Untreated HMEC-1 at 2 and 21 hours were used as controls.In total, 12 samples were analyzed.

2016-08-21 | E-GEOD-69996 | biostudies-arrayexpress

Whole-transcriptome profiling analysis of first trimester placental villi in Indian women

Project description:Whole-transcriptome profiles of individual human placental villi samples from twenty-five (25) Indian women with normal pregnancies during 6- to 8-weeks of gestation were examined using human whole genome expression arrays (NimbleGen 135K). The present study focused on the whole-transcriptome profiling using NimbleGen135K (070925_HG18_exp__12X135K) human whole genome expression arrays of individual human placental villi samples obtained from twenty-five (25) proven-fertile women bearing normal pregnancies voluntarily terminated between 6- and 8-weeks of gestation. Gestational age was estimated from menstrual history, physical and ultrasonographic evaluation. No case of complicated pregnancy from infection, and other significant fetal and maternal clinical indications was included. These twenty five (25) samples include biological replicates of 6, 7 and 8 weeks placental villi samples.

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Differences in molecular expression in cases of non-viable ectopic and intrauterine pregnancies

Project description:Ectopic pregnancy is the leading cause of morbidity and mortality among women in the first trimester. A reliable diagnostic test for the detection of ectopic pregnancy in cases of non-viable pregnancy of unknown location (NV-PUL) is needed. The objective of the current study is to define differences in molecular expression profiles in ectopic and abnormal intrauterine pregnancies toward discovery of biologically plausible ectopic classifier candidate. These samples come from a prospective cohort study comparing transcriptome profiles from women with ectopic pregnancy (ECT) or non-viable intrauterine pregnancy (NV-IUP). Samples were analyzed with the Affymetrix Human Gene 2.0 ST Array. The views expressed are those of the author(s) and do not reflect the official policy of the Department of the Army, the Department of Defense or the U.S. Government. The investigators have adhered to the policies for protection of human subjects as prescribed in 45 CFR 46.

2018-05-31 | GSE112879 | GEO

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