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Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity

ABSTRACT: Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity

PROVIDER: PRJNA767851 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16188429_1.fastq.gz	Fastqsanger.gz
	SRR16188429_2.fastq.gz	Fastqsanger.gz
	SRR16188430_1.fastq.gz	Fastqsanger.gz
	SRR16188430_2.fastq.gz	Fastqsanger.gz
	SRR16188431_1.fastq.gz	Fastqsanger.gz

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Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity [MOR23]

Project description:Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity [MOR23]

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Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity [scRNAseq_MOE_rest]

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Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity [M71]

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Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity [scRNAseq_MOE_rest]

Project description:In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of the extensive parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of mouse olfactory sensory neuron populations are already highly divergent, specific to the olfactory receptor they express, and are surprisingly associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to massive reprogramming via the modulation of transcription. These findings highlight a broad range of sensory neuron identities that are present at rest and that adapt to the experience of the individual, thus adding to the complexity and flexibility of sensory coding.

2022-05-02 | GSE185251 | GEO

Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity [MOR23]

2022-05-02 | GSE185167 | GEO

Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity [M71]

2022-05-02 | GSE185166 | GEO

Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.

Project description:In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of the parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of mouse olfactory sensory neuron populations are already divergent, specific to the olfactory receptor they express, and are associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to reprogramming via the modulation of transcription. These findings highlight a broad range of sensory neuron identities that are present at rest and that adapt to the experience of the individual, thus adding to the complexity and flexibility of sensory coding.

| S-EPMC9132991 | biostudies-literature

single olfactory sensory neurons

Project description:single olfactory sensory neurons

| PRJEB7425 | ENA

single olfactory sensory neurons

Project description:Next generation sequencing of single olfactory sensory neurons during development (whole transcriptome)

2016-03-31 | E-MTAB-2974 | biostudies-arrayexpress

Transcription profiling of mouse olfactory sensory neurons

Project description:The overall aim of the experiment is to understand the phenotype of mature mouse olfactory sensory neurons by analyzing the transcripts expressed and enriched in them as compared to the rest of the cell types in the olfactory epithelium (consisting of immature neurons, supporting cells, progenitor cells and cells in lamina propria) and brain ( with out the olfactory bulbs). Comparision with the other cell types in the olfactory epithelium should eliminate the transcripts commonly expressed in the olfactory epithelium and comparision with brain will eliminate the transcripts common to most neurons. Our gene chip data indicates that mature mouse olfactory sensory neurons express 10,000 genes. Mature OSNs specifically contained three clusters of over represented Gene ontology categories: smell, ion transport and cilia. Analysis for the functionally over represented categories among the transcripts with a positive signal in the mature OSNs yielded largely broad categories common to all cells with the exception of chromatin modelling and RNA processing categories. Biological process categories of movement, development and immune response came as under represented categories. Experiment Overall Design: To purify mature olfactory neurons we took advantage of the OMP-GFP mice. OMP(olfactory marker protein) is expressed specifically in mature olfactory and vomeronasal sensory neurons. In the OMP-GFP mice the coding region of OMP is replaced by GFP. We purified OSNs from the rest of the epithelium from these mice by using FACS. . We used the Affymetrix gene chips mouse expression set 430 (consisting of 430A and 430B chips). Our gene chip data is extensively validated by insitu hybridizations.

2008-06-13 | E-GEOD-4915 | biostudies-arrayexpress

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