Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human Vg9Vd2 T cells develop within the postnatal thymus via a three-stage pathway defined by distinct molecular and cellular changes

ABSTRACT: Human Vg9Vd2 T cells develop within the postnatal thymus via a three-stage pathway defined by distinct molecular and cellular changes

PROVIDER: PRJNA769669 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR16248700_1.fastq.gz	Fastqsanger.gz
	SRR16248700_2.fastq.gz	Fastqsanger.gz
	SRR16248692_1.fastq.gz	Fastqsanger.gz
	SRR16248692_2.fastq.gz	Fastqsanger.gz
	SRR16248693_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Human Vg9Vd2 T cells develop within the postnatal thymus via a three-stage pathway defined by distinct molecular and cellular changes

Project description:We identify precursors to the Vg9Vd2 T cell lineage in the postnatal thymus and use RNA-sequencing to understand their changes in gene expression throughout development

2023-05-11 | GSE185559 | GEO

Human Early Postnatal Thymus [CITE-seq]

Project description:Within the thymus, regulation of the cellular cross-talk directing T cell development is dependent on spatial interactions within specialized niches. To create a holistic, spatially defined map of tissue niches guiding postnatal T cell development we employed the multidimensional imaging platform CO-detection by indEXing (CODEX), as well as Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq) and Assay for Transposable-Accessible Chromatin (ATAC-seq). We generated age-matched 4–5-month-old postnatal thymus datasets for both male and female donors, and describe signaling and cell-cell interaction networks in sequential thymocyte developmental niches. Together, these data represent a unique age-matched spatial multiomic resource to investigate how sex-based differences in thymus regulation and T cell development arise, and provide an essential resource to understand the mechanisms underlying immune function and dysfunction in males and females.

2024-08-30 | GSE264587 | GEO

Human Early Postnatal Thymus [ATAC-seq]

2024-08-30 | GSE264585 | GEO

Human Early Postnatal Thymus [CITE-seq]

Project description:Human Early Postnatal Thymus [CITE-seq]

| PRJNA1103190 | ENA

Human Early Postnatal Thymus [ATAC-seq]

Project description:Human Early Postnatal Thymus [ATAC-seq]

| PRJNA1103192 | ENA

Single-cell RNA sequencing data (SORT-seq) of Treg cells in the human postnatal thymus

Project description:We have performed single-cell RNA sequencing to investigate human regulatory T cell development in the thymus. Treg cells were isolated from a postnatal thymus derived from a 7-week old infant. We examined the composition of the Treg cell compartment in the human thymus and aimed to dissect developmental pathways in Treg cell development.

2021-11-08 | E-MTAB-11019 | biostudies-arrayexpress

miR-145 transgenic mice develop cardiopulmonary complications leading to postnatal death

Project description:miR-145 transgenic mice develop cardiopulmonary complications leading to postnatal death

| PRJNA862172 | ENA

microRNA-seq from thymus (ENCSR047EJT)

Project description:miRNA-seq on postnatal 0 day mouse thymus For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf https://www.encodeproject.org/ENCSR047EJT/

2016-06-22 | E-GEOD-82377 | biostudies-arrayexpress

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes

Project description:During postnatal life, thymopoiesis depends on the continuous colonization of the thymus by bone marrow-derived hematopoietic progenitors that migrate through the bloodstream. The current understanding of the nature of thymic immigrants is largely based on data from pre-clinical models. Here, we employed single-cell RNA sequencing (scRNA-seq) to examine the immature postnatal thymocyte population in humans. Integration of bone marrow and peripheral blood precursor datasets identified two putative thymus seeding precursors that varied in expression of CD7; CD10; and the homing receptors CCR7, CCR9, and ITGB7. Whereas both precursors supported T cell development, only one contributed to intrathymic dendritic cell (DC) differentiation, predominantly of plasmacytoid dendritic cells. Trajectory inference delineated the transcriptional dynamics underlying early human T lineage development, enabling prediction of transcription factor (TF) modules that drive stage-specific steps of human T cell development. This comprehensive dataset defines the expression signature of immature human thymocytes and provides a resource for the further study of human thymopoiesis.

2020-04-17 | GSE144870 | GEO

DNase-seq from thymus (ENCSR935RRY)

Project description:DNase-seq on postnatal mixed mouse thymus For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2016-06-22 | GSE83185 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data