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Transcriptomics analysis of iron chelator deferoxamine treated human tumor colonoids.

ABSTRACT: Transcriptomics analysis of iron chelator deferoxamine treated human tumor colonoids.

PROVIDER: PRJNA770643 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16299762.fastq.gz	Fastqsanger.gz
	SRR16299763.fastq.gz	Fastqsanger.gz

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Transcriptomics analysis of iron chelator deferoxamine treated human tumor colonoids.

Project description:To investigate the detailed molecular mechanisms for the regulatory role of iron in colorectal cancer, RNA-seq analysis was performed on RNA isolated from untreated control and deferoxamine treated human tumor colonoids.

2023-08-01 | GSE185738 | GEO

Treatment of a human lymphoblastoid cell line with the iron chelator deferoxamine

Project description:We treated lymphoblast cells with the iron chelator deferoxamine (DFO) for 60 hours to determine if iron chelation would affect the levels of intron lariats.

2022-03-23 | GSE199077 | GEO

ChIP-seq analysis to examine the effect of the iron chelator deferoxamine on histone methylation levels in 3T3-L1 pre-adipocyte cells

Project description:Adipocyte differentiation has been shown to require iron, but the underlying mechanism remains elusive. Ferrous iron ion is known to function as a co-factor for alpha-ketoglutarate-dependent dioxygenases, including demethylases for histones, DNA, and RNA. Previously we reported several alpha-ketoglutarate-dependent histone demethylases as critical epigenetic regulators during adipogenesis. These lines of evidence led us to hypothesize that iron orchestrates epigenetic/epitranscriptional regulations during adipogenesis by controlling demethylation activities. In this study, we conducted genome-wide analysis on methylation landscapes of histones, DNA, and RNA in differentiation of 3T3-L1 pre-adipocytes. Using the iron chelator deferoxamine, we demonstrate here how dynamically methylation levels of histones, DNA, and RNA are regulated by iron during adipogenesis.

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RNA-seq analysis to examine the effect of the iron chelator deferoxamine on gene expression profile in 3T3-L1 pre-adipocyte cells

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Treatment of a human lymphoblastoid cell line with the iron chelator deferoxamine

Project description:Treatment of a human lymphoblastoid cell line with the iron chelator deferoxamine

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Whole genome bisulfite sequencing analysis to examine the effect of the iron chelator deferoxamine on DNA methylation levels in 3T3-L1 pre-adipocyte cells

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CITE-seq of LSK cells from aged mice after long-term iron chelator regimen

Project description:We found that iron chelation restored functional defects in aged HSC, including engraftment potential and platelet bias. To gain molecular insights into iron-dependent mechanism for sustaining HSC identity during aging, we performed Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq) with lineage (Lin)− Sca-1+ cKit+ (LSK) cells isolated from aged mice after long-term regimens with iron chelator Deferoxamine or vehicle control.

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Single cell RNA-seq of mouse HSC treated with iron chelator deferoxamine (DFO)

Project description:Single cell RNA-seq of mouse HSC treated with iron chelator deferoxamine (DFO)

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Analyses to examine the effect of the iron chelator deferoxamine on 3T3-L1 pre-adipocyte cells

Project description:Analyses to examine the effect of the iron chelator deferoxamine on 3T3-L1 pre-adipocyte cells

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Change expression of genes in iron chelation and deficient conditions

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