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ABSTRACT: Comparative transcriptomics of Lake Malawi cichlid lower oral jaws

PROVIDER: PRJNA770845 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16888424_1.fastq.gz	Fastqsanger.gz
	SRR16888424_2.fastq.gz	Fastqsanger.gz
	SRR16888425_1.fastq.gz	Fastqsanger.gz
	SRR16888425_2.fastq.gz	Fastqsanger.gz
	SRR16888426_1.fastq.gz	Fastqsanger.gz

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Project description:Comparative transcriptomics of Lake Malawi cichlid lower pharyngeal jaws

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Project description:Here we use single nuclei RNA sequencing (snRNA-seq) of replacement teeth and adjacent oral lamina in Lake Malawi cichlids, species with lifelong whole-tooth replacement, to make two main discoveries. First, despite hundreds of millions of years of evolution, we demonstrate conservation of cell type gene expression across vertebrate teeth (fish, mouse, human). Second, we used an approach that combines marker gene expression and developmental potential of dental cells to uncover the transcriptional signature of stem-like cells in regenerating teeth. Our work underscores the importance of a comparative framework in the study of vertebrate oral and regenerative biology.

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