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Genes differentially expressed in bone marrow mesenchymal stem cells (BMSCs) between the control mice (rhebFL/FL) and rheb BAD KO mice (Ucp1-cre rhebFL/FL)

ABSTRACT: genes differentially expressed in bone marrow mesenchymal stem cells (BMSCs) between the control mice (rhebFL/FL) and rheb BAD KO mice (Ucp1-cre rhebFL/FL)

PROVIDER: PRJNA772589 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16477930_1.fastq.gz	Fastqsanger.gz
	SRR16477930_2.fastq.gz	Fastqsanger.gz
	SRR16477931_1.fastq.gz	Fastqsanger.gz
	SRR16477931_2.fastq.gz	Fastqsanger.gz
	SRR16477932_1.fastq.gz	Fastqsanger.gz

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genes differentially expressed in brown adipose tissue between the control mice (rheb FL/FL) and rheb BAD KO mice (Ucp1-cre rheb FL/FL)

Project description:genes differentially expressed in brown adipose tissue between the control mice (rheb FL/FL) and rheb BAD KO mice (Ucp1-cre rheb FL/FL)

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genes differentially expressed between the control mice (rhebFL/FL) and rheb BAD KO mice (Ucp1-cre rhebFL/FL)

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genes differentially expressed in brown adipose tissue between the control mice (rheb FL/FL) and rheb BAD KO mice (Ucp1-cre; rheb FL/FL)

Project description:RNA sequencing was performed to analyze expression profile in brown adipose tissue with or without rheb knockout.

2021-10-21 | GSE186093 | GEO

genes differentially expressed in bone marrow mesenchymal stem cells (BMSCs) between the control mice (rhebFL/FL) and rheb BAD KO mice (Ucp1-cre; rhebFL/FL)

Project description:RNA sequencing was performed to analyze expression profile in BMSCs from mice with or without BAT-specific rheb knockout.

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Microarray on T-Rheb -/- CD4+ and CD8+ cells

Project description:A microarray was performed on T-Rheb -/- (CD4 cre positive Rheb fl/fl) and Wt C57B6J CD4+ and CD8+ cells. T-Rheb -/- mice had reduced fasting blood glucose and we were interested to see if there was a difference in the T cells that could mediate our phenotype.

2021-01-01 | GSE156529 | GEO

genes differentially expressed between the control mice (rhebFL/FL) and rheb BAD KO mice (Ucp1-cre; rhebFL/FL)

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-10-21 | GSE186094 | GEO

Effect of Rheb depletion of Rheb and Ribo-HA knock-in on gene expression of neurons

Project description:To examine the effect of neuronal Rheb on brain myelination, we generated a conditional neuronal Rheb knockout mouse line.

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Amino acid licensing of regulatory T cell function requires signaling via small G proteins Rag and Rheb

Project description:Amino acids license Treg cell function by priming and sustaining TCR induced mTORC1 activity and Rag and Rheb GTPases as central regulators of mTORC1 activation in effector Treg (eTreg) cells RNA was purified from CD25+ Treg cells isolated from Cd4CreRragafl/flRragabfl/fl or Cd4CreRhebfl/flRhebl1–/– mice or their littermate controls.

2019-11-04 | GSE135739 | GEO

Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.

Project description:Rheb, a ras-like small GTPase conserved from human to yeast, controls Tor kinase and plays a central role in regulation of cell growth depending on extracellular conditions. Fission yeast Rheb regulates amino acid uptake as well as response to nitrogen starvation. In this study we generated two mutants of Rheb, rhb1-DA4 and rhb1-DA8, and characterized them genetically. V17A mutation within the G1 box defined for the ras-like GTPases was responsible for rhb1-DA4, and Q52R I76F within the switch II domain for rhb1-DA8. In fission yeast, two events, induction of a meiosis initiating gene mei2+ and cell division without cell growth, are a typical response to nitrogen starvation. Under nitrogen-rich conditions, Rheb stimulates Tor kinase, which, in turn, suppresses the response to nitrogen starvation. While amino acid uptake was prevented by both rhb1-DA4 and rhb1-DA8 in a dominant fashion, the response to nitrogen starvation was prevented only by rhb1-DA4. rhb1-DA8 thereby allowed genetic dissection of the Rheb-dependent signaling cascade. We postulate that Rheb in fission may have two downstream elements, Tor kinase for regulation of the response to nitrogen starvation and the other element for regulation of amino acid uptake. Gene expression profile under nitrogen starvation in fission yeast. Type of experiment: Comparing between vegetatively-growing control cells and cells 3 hrs after nitrogen starvation. Experimental factor: Gene expression profile after nitrogen starvation in the rhb1-D4 or rhb1-D8 cells. Quality control steps taken: All experiments were repeated more than twice except for the tsc2D which was previously reported. Keywards: Nitrogen starvation, rhb1-D4, rhb1-D8

2009-09-28 | E-GEOD-14626 | biostudies-arrayexpress

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