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Rapid Acceleration of Diagnostics - Radical (RADx-rad): Early Detection, Containment, and Management of COVID-19 in Dialysis Facilities Using Multi-Modal Data Sources

ABSTRACT: Rapid Acceleration of Diagnostics - Radical (RADx-rad): Early Detection, Containment, and Management of COVID-19 in Dialysis Facilities Using Multi-Modal Data Sources

PROVIDER: PRJNA773170 | ENA |

REPOSITORIES: ENA

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Rapid Acceleration of Diagnostics - Radical (RADx-rad): Early Detection, Containment, and Management of COVID-19 in Dialysis Facilities Using Multi-Modal Data Sources

Project description:Rapid Acceleration of Diagnostics - Radical (RADx-rad): Early Detection, Containment, and Management of COVID-19 in Dialysis Facilities Using Multi-Modal Data Sources

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Project description:Transcriptome analysis of two population of peritoneal mononuclear phagocytes (CD14+ macrophages and CD1c+ dendritic cells) in peritoneal dialysis effluent from stable (infection-free) peritoneal dialysis patients.

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Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

Project description:The antiviral immune response to SARS-CoV-2 infection can limit viral spread and prevent development of pneumonic COVID-19. However, the protective immunological response associated with successful viral containment in the upper airways remain unclear. Here, we combine a multiomics approach with longitudinal sampling to reveal temporally resolved protective immune signatures in non-pneumonic and ambulatory SARS-CoV-2 infected patients and associate specific immune trajectories with upper airway viral containment. We see a distinct systemic rather than local immune state associated with viral containment, characterized by interferon stimulated gene (ISG) upregulation across circulating immune cell subsets in non-pneumonic SARS-CoV2 infection. We report reduced cytotoxic potential of Natural Killer (NK) and T cells, and an immune-modulatory monocyte phenotype with protective immunity in COVID-19. Together, we show protective immune trajectories in SARS-CoV2 infection, which have important implications for patient prognosis and the development of immunomodulatory therapies.

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AUTOPHAGY ACTIVATION IN PERIPHERAL BLOOD MONONUCLEAR CELLS OF PERITONEAL DIALYSIS PATIENTS

Project description:The complete systemic deregulated biological network in peritoneal dialysis (PD) patients is still only partially defined. High-throughput/omics techniques may offer the possibility to analyze the main biological fingerprints associated with this clinical condition. For the transcriptomic part of the study, we analyzed new data from 10 patients undergoing peritoneal dialysis .

2023-12-31 | E-MTAB-12875 | biostudies-arrayexpress

Morphology and transcriptome of Atlantic salmon skin after seawater transfer, comparison of a semi-closed containment system and open net-pen

Project description:Development of semi-closed containment systems is a promising strategy to further expand Atlantic salmon production. The technology operates with higher production intensities where skin integrity is recognized as a central factor for animal health and welfare. This study investigate the skin development and its immune status in healthy Atlantic salmon growers reared in a semi-closed containment system and a traditional open net-pen system (control).

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Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

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Biological Determinants of Peritoneal Dialysis Outcomes

Project description:Biological Determinants of Peritoneal Dialysis Outcomes

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Biological Determinants of Peritoneal Dialysis Outcomes

Project description:Biological Determinants of Peritoneal Dialysis Outcomes

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Mechanisms for HIV containment in CD4 T cells under homeostatic proliferation

Project description:The main obstacle in curing an established HIV-1 infection is the long-lived reservoir of latently infected CD4+ T cells. This reservoir is maintained by T cell expansion that can be activated by several mechanisms including antigen-driven proliferation and homeostatic proliferation (HSP). Antigen-driven proliferation triggered by T cell receptor (TCR) signaling is a strong physiological inducer of CD4+ T cell expansion. This also reactivates latent HIV-1 and thus, can be the source of viral rebound. Unlike antigen-driven proliferation, HSP allows the expansion of HIV-1-infected CD4+ T cells without activating HIV-1 expression. While this condition strongly activates STAT5 signaling, the mechanisms for HIV-1 containment are unknown. Our previous work using HIV-infected primarily CD4+ T cells maintained under HSP conditions suggested a post-transcriptional block as a cause of the containment (Tsunetsugu-Yokota et al. 2016 Front Microbiol). To decipher the mechanisms that contribute to the HIV-1 refractory state in homeostatic proliferating CD4+ T cells, we analyzed differentially expressed genes in primary CD4 + cells that were cultured either under HSP conditions (culture with IL-7 and IL-15) or after TCR-stimulation (culture with IL-2 after anti-CD3/CD28 activation).

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Project description:Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): SARS-COV-2 Screening in Dialysis Facilities: Building an Optimal Strategy to Protect High Risk Population

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