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Transcriptomic profiles of OASL knockdown HUVECs under basal or activated condition

ABSTRACT: Transcriptomic profiles of OASL knockdown HUVECs under basal or activated condition

PROVIDER: PRJNA773486 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16525276_1.fastq.gz	Fastqsanger.gz
	SRR16525276_2.fastq.gz	Fastqsanger.gz
	SRR16525277_1.fastq.gz	Fastqsanger.gz
	SRR16525277_2.fastq.gz	Fastqsanger.gz
	SRR16525278_1.fastq.gz	Fastqsanger.gz

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Transcriptomic profiles of OASL knockdown HUVECs under basal or activated condition

Project description:Purpose: The goal of this study is to compare endothelial transcriptome affected by OASL knockdown under basal or stimulated conditions by utilizing RNA-seq. Methods: Endothelial mRNA profilies of siCTL or siOASL transfected HUVECs were generated by illumina sequencing method, in duplicate. Following an optimized data analysis workflow, RNA sequence reads were counted using StringTie-2.1.3b and used to identify genes differentially expressed between siCTL- and siOASL-transfected HUVECs treated with or without TNFα and IFNγ. Results: DESeq2 was used to identify genes differentially expressed between siCTL- and siOASL-transfected HUVECs under basal or stimulated conditions. Genes showing <10 read counts total were pre-filtered. Conclusions: Our study represents the first analysis of endothelial mRNA affected by OASL knockdown with biologic replicates, generated by RNA-seq.

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