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Photoactivatable senolysis with single-cell resolution reverses aging

ABSTRACT: Photoactivatable senolysis with single-cell resolution reverses aging

PROVIDER: PRJNA774276 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16562000_1.fastq.gz	Fastqsanger.gz
	SRR16562000_2.fastq.gz	Fastqsanger.gz
	SRR16562001_1.fastq.gz	Fastqsanger.gz
	SRR16562001_2.fastq.gz	Fastqsanger.gz
	SRR16561990_1.fastq.gz	Fastqsanger.gz

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Photoactivatable senolysis with single-cell resolution reverses aging

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Photoactivatable senolysis with single-cell resolution reverses aging

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Photoactivatable senolysis with single-cell resolution reverses aging

Project description:Emerging evidence supports the use of pharmaceutical interventions to target senescent cells (SnCs) and induce their death (senolysis) to extend a healthy lifespan. The challenge then becomes how to achieve precise, broad-spectrum and tractable senolysis. To this end, we have designed a novel senotherapeutic agent with an unprecedented integrated strategy

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Project description:The risk of type 2 diabetes increases with age. Although changes in function and proliferation of aged beta cells resemble those preceding the development of diabetes, the contribution of beta cell aging and senescence remains unclear. The proportion of aged beta cells increases with animal age but even in young mice, senescent beta cells can be found. We showed that different models of insulin resistance accelerated aging and senescence marker expression in beta cells, BGal, led to loss of function and impaired glucose tolerance. Clearance of p16Ink4a+ cells, using the INK-ATTAC mouse model, ameliorated glucose metabolism, insulin secretion and decreased expression of aging, senescence and SASP genes in pancreatic islets. Senolytic drug ABT263 also improved glucose metabolism and beta cell identity when administered during insulin resistance. Human beta cells from diabetic and non-diabetic donors shared some of the same biology laying the foundation for translation into humans. These novel findings lay the framework to pursue senolysis of beta cells as a preventive and alleviating strategy for T2D.

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Aging Fly Cell Atlas Identifies Exhaustive Aging Features at Cellular Resolution

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Deciphering Primate Retinal Aging at Single-Cell Resolution

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Deciphering Primate Retinal Aging at Single-Cell Resolution

Project description:The retina is a light-sensitive highly-organized tissue, which is vulnerable to aging and age-related retinal diseases. However, the effects of aging on retinal cell types including those present in neural retina and retinal pigment epithelium (RPE), as well as cell types in choroid layer remain largely unknown. Here, we established the single-cell transcriptomic atlas of the retina and adjacent choroid in young and aged non-human primates (NHPs), identifying 15 cell types with distinct gene expression signatures and finding several novel markers. Our analysis reveals that oxidative stress is a major aging feature of the cells in the neural retinal layer, whereas an enhanced inflammatory response is that of RPE and choroidal cells. We also found that the RPE cell is the cell type most susceptible to aging in retina, as evidenced by the decreased cell density as well as the highest numbers of differentially expressed genes overlapping with genes underlying aging and aging-related retinal diseases, along with aberrant cell-cell interactions with its two adjacent layers. Altogether, our study provides the roadmap for understanding retinal aging in a NHP model at single-cell resolution, enabling the identification of new diagnostic biomarkers and potential therapeutic targets for age-related human retinal disorders.

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Transcriptomic signatures of the aging brain at bulk-tissue resolution

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