Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Protective effects of ginsenoside Rh2 on doxorubicin damaged hearts from breast tumor bearing mice

ABSTRACT: Protective effects of ginsenoside Rh2 on doxorubicin damaged hearts from breast tumor bearing mice

PROVIDER: PRJNA775988 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR16612553_1.fastq.gz	Fastqsanger.gz
	SRR16612553_2.fastq.gz	Fastqsanger.gz
	SRR16612554_1.fastq.gz	Fastqsanger.gz
	SRR16612554_2.fastq.gz	Fastqsanger.gz
	SRR16612555_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Protective effects of ginsenoside Rh2 on doxorubicin damaged hearts from breast tumor bearing mice

Project description:The FDA approved drug Doxorubicin provokes copious irreversible cardiotoxicity and even increases the risk of heart failure. Considering the multiple and interacted molecular pathways in cancer, there is a big possibility that tumors are simultaneously sensitive to different drugs. This makes achievable to study the combinations of drug, having the virtues of less toxicity, higher efficacy and potentially antagonizing drug resistance in cancer therapy. In the present study, we addressed the synergistic effects of ginsenoside Rh2 on doxorubicin-treated breast cancer bearing mice. We showed that Rh2 significantly enhanced the antitumor effects of doxorubicin and greatly attenuated the cardiotoxicity. Transcriptomic changes can clearly distinguish the chemotherapeutic groups and non-treated control groups. Transcriptomic analysis domestrated that Rh2 protection involved in multiple vital pathways including cellular senescece, fibrosis remodeling, apoptosis and inflammation.

2021-10-30 | GSE186765 | GEO

Anti-cnacer effects of ginsenoside Rh2 with doxorubicin from breast tumor bearing mice

Project description:The FDA approved drug Doxorubicin provokes copious irreversible cardiotoxicity and even increases the risk of heart failure. Considering the multiple and interacted molecular pathways in cancer, there is a big possibility that tumors are simultaneously sensitive to different drugs. This makes achievable to study the combinations of drug, having the virtues of less toxicity, higher efficacy and potentially antagonizing drug resistance in cancer therapy. In the present study, we addressed the synergistic effects of ginsenoside Rh2 on doxorubicin-treated breast cancer bearing mice. We showed that Rh2 significantly enhanced the anti-cancer effects of doxorubicin and greatly attenuated the cardiotoxicity. Transcriptomic changes can clearly distinguish the chemotherapeutic groups and non-treated control groups. Transcriptomic analysis domestrated that Rh2 protection involved in multiple vital pathways including cellular stress, apoptosis and inflammation.

2021-10-28 | GSE186555 | GEO

Anti-cnacer effects of ginsenoside Rh2 with doxorubicin from breast tumor bearing mice

Project description:Anti-cnacer effects of ginsenoside Rh2 with doxorubicin from breast tumor bearing mice

| PRJNA774507 | ENA

Ginsenoside Rh2 epigenetically regulates cell-mediated immune pathway to inhibit proliferation of the MCF-7 breast cancer cell

Project description:Genome wide DNA methylation profiling of estrogene receptor postive breast cancer cell line MCF-7, treating Ginsoenoside Rh2. The Illumina Infinium Human Methylation EPIC v1.0 B2 Bead chip was used to obtain DNA methylation profiles across approximately 850,000 CpGs. This profiling indicates that Ginsenoside Rh2 induces epigenetic and cellular changes.

2017-07-30 | GSE93356 | GEO

Comparison of the Damaged Cartilage with the Non-weight Bearing Healthy Cartilage

Project description:Comparison of the Damaged Cartilage with the Non-weight Bearing Healthy Cartilage

| PRJNA530239 | ENA

Transcription profiling of rat hearts isolated perfused and exposed to doxorubicin

Project description:We used microarrays to detail transcriptional changes in the rat heart in response to doxorubicin, a chemotherapeutic drug known to induce cardiac disfunction/heart failure Experiment Overall Design: Langendorff perfusion of isolated hearts with/without doxorubicin

2009-01-14 | E-GEOD-12260 | biostudies-arrayexpress

Comparison of the Damaged Cartilage with the Non-weight Bearing Healthy Cartilage

Project description:The cartilage samples from patient with Internatinaol Cartilage Repair Society's Scoring 3-4 cartilage defects were analysed in order to understand the differences between healthy and damaged cartilage tissues from the knee.

2019-04-02 | GSE129147 | GEO

Expression data from isolated perfused rat hearts exposed to doxorubicin

2008-12-31 | GSE12260 | GEO

Effects of Ginseng Berries Concentrate and Ginsenoside Re on gene expression profiles.

Project description:C2C12 myocytes were treated with Ginseng Berries Concentrate and Ginsenoside Re to identify gene expression changes.

2024-03-03 | GSE259316 | GEO

Detoxifying doxorubicin

Project description:Detoxifying doxorubicin

| PRJNA422761 | ENA