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Mouse Osteoblast Differentiation RNA-seq analysis

ABSTRACT: Mouse Osteoblast Differentiation RNA-seq analysis

PROVIDER: PRJNA776260 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16636661.fastq.gz	Fastqsanger.gz
	SRR16636662.fastq.gz	Fastqsanger.gz
	SRR16636663.fastq.gz	Fastqsanger.gz
	SRR16636664.fastq.gz	Fastqsanger.gz
	SRR16636665.fastq.gz	Fastqsanger.gz

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Project description:The expression of Glis3 in C3H10T1/2 cells promotes osteoblastic differentiation as indicated by the the induction of increase in alkaline phosphatase activity, an early marker of osteoblast differentiation, and increased expression of osteopontin, a late marker of osteogenesis. Glis3 acts synergistically with bone morphogenic protein 2 (BMP-2). In contrast, expression of Glis3 inhibits the induction of adipocyte differentiation. Microarray analysis identified the fibroblast growth factor 18 (FGF18) as one of the genes induced by Glis3 in C3H10T1/2 cells directly. Keywords: Glis3, osteoblast differentiation, adipocyte differentiation, FGF18, BMP2

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