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Next-generation sequencing of CUT&RUN of MKL-1 Merkel cell carcinoma cells treated with EPZ011989

ABSTRACT: Next-generation sequencing of CUT&RUN of MKL-1 Merkel cell carcinoma cells treated with EPZ011989

PROVIDER: PRJNA776721 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16674825_1.fastq.gz	Fastqsanger.gz
	SRR16674825_2.fastq.gz	Fastqsanger.gz
	SRR16674826_1.fastq.gz	Fastqsanger.gz
	SRR16674826_2.fastq.gz	Fastqsanger.gz
	SRR16674827_1.fastq.gz	Fastqsanger.gz

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Next-generation sequencing of CUT&RUN of MKL-1 Merkel cell carcinoma cells treated with EPZ011989

Project description:The overarching goal of this study was to characterize mechanisms of sensitivity to EZH2 inhibitors in Merkel cell carcinoma cell lines. To that end, CUT&RUN for H3K27me3 and H3K4me3 histone marks was performed in MKL-1 cells treated with the EZH2 inhibitor EPZ011989 for 6 days.

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Next-generation mRNA sequencing of MKL-1 Merkel cell carcinoma cells treated with EPZ011989

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MKL-1 Merkel cell carcinoma cells treated with EPZ011989

Project description:MKL-1 Merkel cell carcinoma cells treated with EPZ011989

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Next-generation mRNA sequencing of MKL-1 Merkel cell carcinoma cells treated with EPZ011989

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Identification of chromatin states during zebrafish gastrulation using CUT&RUN and CUT&Tag

Project description:Here we describe successful implementation of CUT&RUN for profiling protein-DNA interactions in zebrafish embryos. We apply modified a CUT&RUN method to generate high resolution maps of enrichment for H3K4me3, H3K27me3, H3K9me3, and RNA polymerase II during zebrafish gastrulation. Using this data, we identify a conserved subset of developmental genes that are enriched in both H3K4me3 and H3K27me3 during gastrulation, and we demonstrate the increased effectiveness of CUT&RUN for detecting protein enrichment at repetitive sequences with reduced mappability. Our work demonstrates the power of combining CUT&RUN with the strengths of the zebrafish system to better understand the changing embryonic chromatin landscape and its roles in shaping development.

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2023-12-31 | GSE192496 | GEO

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