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CUT&RUN of TAF4b and H3K4me3 in E16.5 oocytes

ABSTRACT: CUT&RUN of TAF4b and H3K4me3 in E16.5 oocytes

PROVIDER: PRJNA777234 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16694274_1.fastq.gz	Fastqsanger.gz
	SRR16694274_2.fastq.gz	Fastqsanger.gz
	SRR16694275_1.fastq.gz	Fastqsanger.gz
	SRR16694275_2.fastq.gz	Fastqsanger.gz
	SRR16694276_1.fastq.gz	Fastqsanger.gz

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CUT&RUN of TAF4b and H3K4me3 in E16.5 oocytes

Project description:Research has shown that Taf4b-deficient female mice display excessive perinatal germ cell death, delayed germ cell cyst breakdown, and increased chromosome asynapsis. Therefore, we hypothesized that TAF4b, as part of TFIID, regulates oogenesis and meiotic gene programs. However, the direct targets of TAF4b have not been thoroughly explored. Therefore, we performed Cleavage Under Targets and Release Using Nuclease (CUT&RUN) in E16.5 mouse oocytes.

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CUT&RUN of TAF4b and H3K4me3 in E16.5 prospermatogonia

Project description:CUT&RUN of TAF4b and H3K4me3 in E16.5 prospermatogonia

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Project description:Research has shown that Taf4b-deficient female mice display excessive perinatal germ cell death, delayed germ cell cyst breakdown, and increased chromosome asynapsis. Therefore, we hypothesized that TAF4b, as part of TFIID, regulates oogenesis and meiotic gene programs. However, the transcriptomic effects of Taf4b-deficiency and how this may lead to the infertility we observe in mice has not yet been studied. Therefore, we performed RNA-seq to examine gene expression changes in E16.5 female Taf4b-heterozygous and Taf4b-deficient germ cells

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