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The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research [RNAseq]

ABSTRACT: The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research [RNAseq]

PROVIDER: PRJNA777839 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16770718.fastq.gz	Fastqsanger.gz
	SRR16770719.fastq.gz	Fastqsanger.gz
	SRR16770720.fastq.gz	Fastqsanger.gz
	SRR16770721.fastq.gz	Fastqsanger.gz
	SRR16770722.fastq.gz	Fastqsanger.gz

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The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research [RRBS]

Project description:Scientific evidence suggests that not only murine scent communication is regulated by major urinary proteins, but that their expression may also vary in response to metabolism via a yet unknown mechanism. Major urinary proteins are expressed mainly in the liver, showing a sexually dimorphic pattern with substantially higher expression in males. Here, we investigate the metabolic implications of a major urinary protein knockout in twelve-week-old male and female C57BL/6N mice during ad libitum feeding. Despite both sexes of major urinary protein knockout mice displayed numerically increased body weight and visceral adipose tissue proportions compared to sex-matched wildtype mice, the main genotype-specific metabolic differences were observed exclusively in males. Male major urinary protein knockout mice exhibited plasma and hepatic lipid accumulation accompanied by a hepatic transcriptome indicating an activation of lipogenesis. These findings match the higher major urinary protein expression in male compared to female wildtype mice, suggesting a more distinct reduction in energy requirements in male compared to female major urinary protein knockout mice. The observed sex-specific anabolic phenotype confirms a role of major urinary protein in metabolism and, since major urinary proteins are not expressed in humans, suggests the major urinary protein knockout mouse as a potential alternative model for translational metabolism research which needs to be further elucidated.

2022-08-01 | GSE188157 | GEO

The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research [RNAseq]

2022-08-01 | GSE188156 | GEO

The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research

Project description:The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research

| PRJNA777833 | ENA

The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research [RRBS]

Project description:The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research [RRBS]

| PRJNA777837 | ENA

The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-01 | GSE188158 | GEO

The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research.

| S-EPMC9343454 | biostudies-literature

Molecular complexity of the major urinary protein system of the Norway rat, Rattus norvegicus C4PR_LIV

Project description:Major urinary proteins (MUP) are the major component of the urinary protein fraction in house mice (Mus spp.) and rats (Rattus spp.). The structure, polymorphism and functions of these lipocalins have been well described in the western European house mouse (Mus musculus domesticus), clarifying their role in semiochemical communication. The complexity of these roles in the mouse raises the question of similar functions in other rodents, including the Norway rat, Rattus norvegicus. Norway rats express MUPs in urine but information about specific MUP isoform sequences and functions is limited. In this study, we present a detailed molecular characterization of the MUP proteoforms expressed in the urine of two laboratory strains, Wistar Han and Brown Norway, and wild caught animals, using a combination of manual gene annotation, intact protein mass spectrometry and bottom-up mass spectrometry-based proteomic approaches. Detailed sequencing of the urinary MUP isoforms reveals a less complex pattern of primary sequence polymorphism in the rat than the mouse. However, rat MUPs exhibit added complexity in the form of post-translational modifications, including the phosphorylation of Ser4 in some isoforms, and exoproteolytic trimming of specific isoforms.

2019-08-01 | PXD013986 | Pride

Quantification of highly homologous Major Urinary Proteins in wild house mice

Project description:Male house mice were housed under semi-natural conditions and their urinary proteins were quantified using MS1 and MS2 based label-free strategies. This dataset consists of 52 raw MS files, comprising 26 DIA (SWATH) and 26 IDA runs on a TripleTOF 5600. The composition of the dataset is described in the manuscript by Enk et al., titled: "Regulation of highly homologous Major Urinary Proteins in house mice quantified with label-free proteomic methods ", Molecular Biosystems, in review.

2016-08-08 | PXD004642 | Pride

Gene expression profiling of patients from the Danish Center for Translational Breast Cancer Research program

Project description:Female breast cancer patients who underwent surgery for breast cancer as part of the Danish Center for Translational Breast Cancer Research program were included from 2003 to 2012. Patient inclusion criteria were: (1) a unifocal tumor with an estimated size of more than 20 mm in diameter, (2) none of the patients had a history of breast surgery and (3) none received preoperative treatment. Patients were defined as high risk according to the Danish Breast Cooperative Group (www.dbcg.dk) and were followed after surgery.

2018-11-16 | E-MTAB-7201 | biostudies-arrayexpress

DNase-seq from urinary bladder (ENCSR813CKU)

Project description:DNase-seq on 76 day old fetal male human urinary bladder tissue For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2016-12-07 | GSE90402 | GEO

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