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Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation

ABSTRACT: Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation

PROVIDER: PRJNA779030 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16890921.fastq.gz	Fastqsanger.gz
	SRR16890922.fastq.gz	Fastqsanger.gz
	SRR16890923.fastq.gz	Fastqsanger.gz
	SRR16890924.fastq.gz	Fastqsanger.gz
	SRR16890925.fastq.gz	Fastqsanger.gz

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Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation [Bulk RNA-seq]

Project description:Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation [Bulk RNA-seq]

| PRJNA779039 | ENA

Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation [Single-cell RNA-seq]

Project description:Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation [Single-cell RNA-seq]

| PRJNA779038 | ENA

Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation [Bulk RNA-seq]

Project description:Consecutive exposures to different pathogens are very common and often alter host immune responses. Yet, it remains unknown how a secondary bacterial infection interferes with an ongoing adaptive immune response elicited against primary invading pathogens. Here, we demonstrate that pre-existing germinal center (GC) B cells are incapable of enduring radical metabolic changes induced by recruited Sca-1+ monocytes during Salmonella Typhimurium (STm) infection. GCs-induced by influenza, plasmodium and commensals deteriorated upon STm infection. GC collapse was independent of direct bacterial interactions with B cells, but rather, was induced through recruitment of CCR2-dependent Sca-1+ monocytes. GC collapse was dependent on non-B cell TLR-4, TNFα and IFNγ, which was essential for Sca-1+ monocyte differentiation in the bone-marrow. Monocyte recruitment and GC disruption also occurred during LPS-supplemented vaccination and Listeria monocytogenes infection. Thus, systemic activation of the innate immune response upon lethal bacterial infection is induced at the expense of antibody-mediated immunity.

2022-11-02 | GSE188474 | GEO

Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation [Single-cell RNA-seq]

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Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-11-02 | GSE188476 | GEO

Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow II

Project description:Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation of their precursors. Here we define human BMPC heterogeneity and track the recruitment of antibody-secreting cells (ASC) from SARS-CoV-2 vaccine immune reactions to the bone marrow (BM). Trajectories based on single-cell transcriptomes and repertoires of peripheral and BM ASC reveal sequential colonisation of BMPC compartments. In activated B cells, IL-21 suppresses CD19 expression, indicating that CD19low-BMPC are derived from follicular, while CD19high-BMPC originate from extrafollicular immune reactions. In primary immune reactions, both CD19low- and CD19high-BMPC compartments are populated. In secondary immune reactions, most BMPC are recruited to CD19high-BMPC compartments, reflecting their origin from extrafollicular reactivations of memory B cells. A pattern also observed in vaccinated-convalescent individuals and upon diphtheria/tetanus/pertussis recall-vaccination. Thus, BMPC diversity reflects the evolution of a given humoral immune response.

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Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow I

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Exacerbated S. aureus foot infections in obese/diabetic mice are associated with impaired germinal center reactions, Ig class-switching, and humoral immunity.

Project description:Exacerbated S. aureus foot infections in obese/diabetic mice are associated with impaired germinal center reactions, Ig class-switching, and humoral immunity.

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c-Rel gain in B cells dose-dependently drives germinal center reactions and autoantibody production in mice

Project description:c-Rel gain in B cells dose-dependently drives germinal center reactions and autoantibody production in mice

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Proteome profiling of mouse germinal center B cells

Project description:Productive B cell responses are critical to protect a host from infection. The spleen and lymph nodes are populated by resting follicular B cells, which can enter germinal centers upon antigen encounter. Once in the germinal center, B cells migrate between the dark and light zones, where they undergo somatic hypermutation and selection, respectively. While germinal center B cells have been studied, an intense molecular understanding of these cells/subsets (and the differences between them) is lacking.

2020-04-06 | PXD015524 | Pride

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