Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of free D-Lactate in CNS pathology

ABSTRACT: Effect of free D-Lactate in CNS pathology

PROVIDER: PRJNA779080 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR16893137_1.fastq.gz	Fastqsanger.gz
	SRR16893137_2.fastq.gz	Fastqsanger.gz
	SRR16893138_1.fastq.gz	Fastqsanger.gz
	SRR16893138_2.fastq.gz	Fastqsanger.gz
	SRR16893139_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Study of the protective effect of D-Lactate-producing probiotics on CNS pathology

Project description:Study of the protective effect of D-Lactate-producing probiotics on CNS pathology

| PRJNA779087 | ENA

Effect of free D-Lactate in CNS pathology

Project description:Dendritic cells (DCs) control the generation of self-reactive pathogenic T cells. Thus, DCs are attractive therapeutic targets for autoimmune diseases. Using single-cell and bulk transcriptional and metabolic analyses in combination with cell-specific gene perturbation studies we identified a negative feedback regulatory pathway that operates in DCs to limit immunopathology. Specifically, we found that lactate, produced by activated DCs and other immune cells, boosts NDUFA4L2 expression through a mechanism mediated by HIF-1a. NDUFA4L2 promotes mitochondrial fitness in DCs, limiting the production of mitochondrial reactive oxygen species that activate XBP1-driven transcriptional modules involved in the control of pathogenic autoimmune T cells. Moreover, we engineered a probiotic that produces lactate and suppresses T-cell autoimmunity in the central nervous system via the activation of HIF-1a/NDUFA4L2 signaling in DCs. In summary, we identified a novel immunometabolic pathway that regulates DC function, and developed a synthetic probiotic for its therapeutic activation via the gut-brain axis.

2023-08-18 | GSE188500 | GEO

Effect of XBP1-deficiency in DCs on CNS pathology

Project description:Effect of XBP1-deficiency in DCs on CNS pathology

| PRJNA779088 | ENA

Study of the protective effect of D-Lactate-producing probiotics on CNS pathology

2023-08-18 | GSE188503 | GEO

Astrocyte-produced HB-EGF limits autoimmune CNS pathology

Project description:Astrocyte-produced HB-EGF limits autoimmune CNS pathology

| PRJNA1028105 | ENA

Astrocyte-produced HB-EGF limits autoimmune CNS pathology [WGBS]

Project description:Astrocyte-produced HB-EGF limits autoimmune CNS pathology [WGBS]

| PRJNA1028108 | ENA