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RNA-sequencing of wild-type, CD97- and Gα13-deficient splenic cDC2s

ABSTRACT: RNA-sequencing of wild-type, CD97- and Gα13-deficient splenic cDC2s

PROVIDER: PRJNA780493 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16947313.fastq.gz	Fastqsanger.gz
	SRR16947314.fastq.gz	Fastqsanger.gz
	SRR16947315.fastq.gz	Fastqsanger.gz
	SRR16947316.fastq.gz	Fastqsanger.gz
	SRR16947317.fastq.gz	Fastqsanger.gz

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Project description:We analyzed the transcriptome differences of wild-type and ArhGEF1-deficient (Arhgef1-/-) type-2 conventional dendritic cells (cDC2s) in spleen. Wild-type or ArhGEF1-deficient (Arhgef1-/-) bone marrow cells were transferred into lethal irradiated CD45.1 mice. 8 weeks later, splenic cDC2s were purified and prepared for RNA-seq analysis. The gene expression profiles of CD97-, Gα13- and ArhGEF1-deficient cDC2s were highly similar, providing evidence that these molecules function in the same pathway.

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