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Danio rerio

ABSTRACT: Tris(1,3-dichloro-2-propyl) phosphate disrupts the normal trajectory of cytosine methylation within developing zebrafish embryos

PROVIDER: PRJNA780909 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18677127_1.fastq.gz	Fastqsanger.gz
	SRR18677127_2.fastq.gz	Fastqsanger.gz
	SRR18677128_1.fastq.gz	Fastqsanger.gz
	SRR18677128_2.fastq.gz	Fastqsanger.gz
	SRR18677129_1.fastq.gz	Fastqsanger.gz

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Expression data from HeLa cell treated with Tris(1,3-dichloro-2-propyl)phosphate

Project description:Tris(1,3-dichloro-2-propyl)phosphate is widely used in consumer products as a flame retardant. Humans are often exposed to this compound. However, the molecular mechanisms of the compound`s adverse effects are still unclear. We address the molecular and cellular mechanisms underlying tris(1,3-dichloro-2-propyl)phosphate effects on HeLa cells. Here RNA-Seq analysis was performed to identify distinct classes of up- or down-regulated genes and their connections to different metabolic pathways.

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Project description:Impacts of tris(1,3-dichloro-2-propyl) phosphate on DNA methylation within early zebrafish embryos

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Project description:Tris(1,3-dichloro-2-propyl) phosphate Exposure During Early-Blastula Alters the Normal Trajectory of Zebrafish Embryogenesis

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Expression data from HeLa cell treated with Tris(1,3-dichloro-2-propyl)phosphate

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Project description:Complex Interplay Among Nuclear Receptors, Cytosine Methylation, and the Metabolome in Driving Tris(1,3-Dichloro-2-Propyl) Phosphate-Induced Epiboly Defects in Zebrafish

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Lysosome-autophagy dysfunction contribute to TDCIPP induced Aβ1-42 production in N2a-APPswe cells.

Project description:Alzheimer's disease is the most common form of dementia characterized on cognitive impairment. Autophagy-lysosome dysfunction is linked to AD pathology. Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is a widely used organophosphorus flame retardants with the potential to induce neuronal damage. We found that TDCIPP significantly increased expression of BACE1 and of Aβ42. TMT labeled proteomic study were used to reveal profile changes of N2a-APPswe cells after exposure by TDCIPP. Proteomic and bioinformatic analysis revealed that lysosomal proteins were dysregulated after TDCIPP treatment in N2a-APPswe cells. LC3, P62, CTSD, and LAMP1 were increased, while STAT1 was decreased after TDCIPP exposure and dysregulated proteins were validated by Western blotting. Our results, for the first time revealed that TDCIPP could be one of potential environment risk factors for AD development. Autophagy dysregulation may take an important role on TDCIPP induced Aβ42 production.

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Mytilus galloprovincialis gills exposed to TDCPP

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