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DNA methylation and transcriptomic signatures in patients with peanut- and multi-food allergy (Methylation)

ABSTRACT: DNA methylation and transcriptomic signatures in patients with peanut- and multi-food allergy (Methylation)

PROVIDER: PRJNA781653 | ENA |

REPOSITORIES: ENA

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DNA methylation and transcriptomic signatures in patients with peanut- and multi-food allergy (Methylation)

Project description:This study profiled the epigenomes and transcriptomes of total nCD4T cell populations from adolescents with peanut-only (single food allergy- SA) and multi-food allergy (MA) at quiescence and following activation with anti-CD3/antiCD28

2022-02-28 | GSE189148 | GEO

DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy [RNA-Seq]

Project description:This study profiled the epigenomes and transcriptomes of total B cell populations from adolescents with peanut-only (single food allergy- SA) and multi-food allergy (MA).

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DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy [array]

Project description:This study profiled the epigenomes and transcriptomes of total B cell populations from adolescents with peanut-only (single food allergy- SA) and multi-food allergy (MA). We found distinct epigenetic and transcriptomic differences between food allergic patients and controls, in addition to SA- and MA- group specific signatures, with

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DNA methylation and transcriptomic signatures in patients with peanut- and multi-food allergy (RNA-Seq)

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Ar101 Oral Desensitization Therapy for Peanut Allergy Induces Dynamic Changes in Peanut-Specific Immune Responses

Project description:Peanut allergy is increasingly prevalent among children in the United States and other industrialized countries and is now estimated to affect approximately 2% of children. While there are currently no approved treatment options, peanut allergy usually persists into adulthood, can be life-threatening, and accounts for most deaths related to food allergy. Here, we track peanut-reactive CD4+ T effector (pTeff) cells using the CD154 up-regulation assay. We found that CRTH2+ pTeff cells and CCR6+ pTeff cells represent two mutually exclusive, non-overlapping cellular and molecular entities involved in food allergic diseases.

2022-08-10 | GSE196495 | GEO

DNA methylation and transcriptomic signatures in patients with peanut- and multi-food allergy

Project description:DNA methylation and transcriptomic signatures in patients with peanut- and multi-food allergy

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DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy

Project description:DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy

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Blood DNA methylation biomarkers predict clinical reactivity in food-sensitized infants

2015-01-01 | GSE59999 | GEO

DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy [array]

Project description:DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy [array]

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Prediction of clinical reactivity in food sensitized individuals from blood DNA methylation profiles

Project description:Genome wide DNA methylation profiling study of PBMC from 71 unique primary patient blood samples. The Illumina Human Methylation 450k array was used. 29 challenge proven food allergy, 29 sensitized but oral tolerant, 13 non food allergics Mixture of food allergy phenotypes (egg allergic (15), peanut allergic (14)), food sensitization phenotypes (egg sensitized (14), peanut sensitized (15)). 4 samples had technical replicate hybridzations. Bisulphite converted DNA from the 75 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip v1.2. Technical replicates were combined during processing, resulting in normalized Beta values for 71 unique primary patient blood samples.

2015-01-01 | E-GEOD-59999 | biostudies-arrayexpress

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