Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Pneumocystis jirovecii

ABSTRACT: Pneumocystis jirovecii Metagenome

PROVIDER: PRJNA782857 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17729727.fastq.gz	Fastqsanger.gz
	SRR17729728.fastq.gz	Fastqsanger.gz
	SRR17729729.fastq.gz	Fastqsanger.gz
	SRR17729730.fastq.gz	Fastqsanger.gz
	SRR17729731.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Pneumocystis jirovecii

Project description:Pneumocystis jirovecii msg genes repertoires

| PRJNA936793 | ENA

Pneumocystis jirovecii TSA

Project description:Transcriptome of Pneumocystis jirovecii during human Pneumocystis pneumonia

| PRJEB370 | ENA

Pneumocystis jirovecii SE8

Project description:Pneumocystis jirovecii SE8 Genome sequencing and assembly

| PRJEA68827 | ENA

Pneumocystis jirovecii strain:E2178

Project description:Pneumocystis jirovecii Genome sequencing and assembly

| PRJNA382815 | ENA

Pneumocystis jirovecii

Project description:Alterations of lung microbiota in lung transplant recipients with Pneumocystis jirovecii pneumonia.

| PRJNA1033798 | ENA

Pneumocystis jirovecii RU12

Project description:Pneumocystis

| PRJNA223508 | ENA

Pneumocystis jirovecii RU817

Project description:Pneumocystis

| PRJNA223509 | ENA

Pneumocystis jirovecii RU7

Project description:Pneumocystis

| PRJNA223510 | ENA

β-glucans are Masked but Contribute to Pulmonary Inflammation During Pneumocystis Pneumonia

Project description:β-glucans, which can activate innate immune responses, are a major component in the cell wall of the cyst form of Pneumocystis. In the current study we examined whether β-1,3 glucans are masked by surface proteins in Pneumocystis, and what role β-glucans play in Pneumocystis-associated inflammation. For 3 species, including P. jirovecii, which causes Pneumocystis pneumonia (PCP) in humans, P. carinii, and P. murina, β-1,3 glucans were masked in most organisms, as demonstrated by increased exposure following trypsin treatment. Using Q-PCR and microarray techniques, we demonstrated in a mouse model of PCP that treatment with caspofungin, an inhibitor of β-1,3 glucan synthesis, for 21 days, decreased expression of a broad panel of inflammatory markers, including IFN-γ, TNF-α, IL-1β, IL-6, and multiple chemokines/chemokine ligands. Thus, β-glucans in Pneumocystis cysts are largely masked, which likely decreases innate immune activation; this mechanism presumably was developed for interactions with immunocompetent hosts, in whom organism loads are substantially lower. In immunosuppressed hosts with a high organism burden, organism death and release of glucans appears to be an important contributor to deleterious host inflammatory responses.

2016-08-31 | GSE79079 | GEO

Pneumocystis jirovecii

Project description:Metagenomic next-generation sequencing and conventional tests unravel pathogen profiles in infected patients undergoing allogeneic hematopoietic stem cell transplantation in Jilin Province

| PRJNA1058277 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data