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DNA methylation patterns in monocytes associate and evolve with prognosis in undifferentiated arthritis [MACs]

ABSTRACT: DNA methylation patterns in monocytes associate and evolve with prognosis in undifferentiated arthritis [MACs]

PROVIDER: PRJNA782987 | ENA |

REPOSITORIES: ENA

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DNA methylation patterns in monocytes associate and evolve with prognosis in undifferentiated arthritis

Project description:DNA methylation patterns in monocytes associate and evolve with prognosis in undifferentiated arthritis

| PRJNA782993 | ENA

DNA methylation patterns in monocytes associate and evolve with prognosis in undifferentiated arthritis [MACs]

Project description:Ontogenic origin of monocytic cells in the synovial fluid is currently under discussion. Also, the polarization of these cells have been described to a play a role in the pathogenic joints of arthritis patients. To answer these questions, we analyzed data from blood and SF monocytes and compared them with those of in vitro-generated monocyte-derived macrophages. All conditions were compared, and differences were characterized, considering experimental condition (MO, M-CSF or GM-CSF), compartment (blood or SF) and patient prognosis (good or poor).

2022-05-25 | GSE189422 | GEO

DNA methylation patterns in monocytes associate and evolve with prognosis in undifferentiated arthritis

Project description:The identification of predictive markers in an early undifferentiated arthritis (UA) patients is pivotal for selecting appropriate therapies to avoid a poor prognosis. In this work, we investigated the association between clinical features and DNA methylation patterns in monocytes from UA patients to seek potential prognostic biomarkers.

2022-05-25 | GSE189426 | GEO

Bacterial Intestinal Gut Modification Around Cancer Surgery (BIG MACS) Diet

Project description:The long-term study objective is to develop optimized nutritional therapies for surgery and test them in clinical practice. This pilot study will test a microbiome-optimization diet in colorectal cancer surgery patients. The study hypothesizes that the Bacterial Intestinal Gut Modification Around Cancer Surgery (BIG MACS) Diet will provide participants with increased microbiota accessible carbohydrates (MACs) to support the microbiome and improve outcomes.

| 2972 | ecrin-mdr-crc

NIAID Mulit-Center AIDS Cohort Study (MACS)

Project description:NIAID Mulit-Center AIDS Cohort Study (MACS)

| PRJNA671317 | ENA

NIAID Mulit-Center AIDS Cohort Study (MACS)

Project description:NIAID Mulit-Center AIDS Cohort Study (MACS)

| PRJNA671318 | ENA

Comparison of microglial proteomes of MACS and FACS-based purified CD11b+ microglia

Project description:Background Proteomic characterization of microglia has been limited by low yield and contamination by non-microglial proteins by magnetic-activated cell sorting (MACS) enrichment strategies. To determine whether a fluorescent-activated cell sorting (FACS)-based strategy overcomes these limitations, we compared microglial proteomes of MACS and FACS-based purified CD11b+ microglia in order to identify core sets of microglial proteins in adult mouse brain tissue. Results Quantitative multiplex proteomics by tandem mass tag mass spectrometry (TMT-MS) of MACS-enriched (N = 5) and FACS-purified (N = 5) adult wild-type CD11b+ microglia identified 1,791 proteins, of which 953 were differentially expressed indicating significant differences between both approaches. While the FACS-purified microglia proteome was enriched with cytosolic, endoplasmic reticulum and ribosomal proteins involved in protein metabolism and immune system functions, the MACS-enriched microglia proteome was enriched with proteins related to mitochondrial function and synaptic transmission. As compared to MACS, the FACS microglial proteome showed strong enrichment for canonical microglial proteins while neuron, astrocyte, and oligodendrocyte proteins were decreased. Interestingly, we observed enrichment of endothelial specific proteins in the FACS microglia proteome. By comparing FACS-purified microglia proteomes with transcriptomes, we observed highly concordant as well as highly discordant proteins that were abundant at the protein level but low at the transcript level. Conclusions We demonstrate that TMT-MS proteomics of FACS-purified adult microglia is superior to column-based enrichment approaches, resulting in purer and highly-enriched microglial proteomes. We also define core sets of highly-abundant adult microglial proteins including Moesin (Msn) that can guide future studies.

2020-05-11 | PXD015652 | Pride

SIMS seawater associate bacteria

Project description:SIMS seawater associate bacteria Raw sequence reads

| PRJNA846510 | ENA

Parenchymal border macrophages regulate CSF flow dynamics [leptomeningeal macs]

Project description:Parenchymal border macrophages regulate CSF flow dynamics [leptomeningeal macs]

| PRJNA778203 | ENA

Analysis of isotope incorporation in differentiated and undifferentiated podocytes

Project description:We subjected podocytes (either differentiated or undifferentiated) to a pulse with stable isotope labeled amino acids for 24, 48, 72 and 96h.

2018-05-01 | PXD006887 | Pride

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