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Glucocorticoids Unmask Silent Non-Coding Genetic Risk Variants for Common Diseases [HiChIP]

ABSTRACT: Glucocorticoids Unmask Silent Non-Coding Genetic Risk Variants for Common Diseases [HiChIP]

PROVIDER: PRJNA783038 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17022156_1.fastq.gz	Fastqsanger.gz
	SRR17022156_2.fastq.gz	Fastqsanger.gz
	SRR17022157_1.fastq.gz	Fastqsanger.gz
	SRR17022157_2.fastq.gz	Fastqsanger.gz

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Project description:30 B-lymphoblastoid cell lines (LCLs) with genome-wide genotype data were treated with hydrocortisone (GR agonist) and CORT108297 (GR modulator), followed by RNA-seq to identify PGx-eQTLs. We then integrated GR chromatin immunoprecipitation-sequencing (ChIP-seq) to characterize the epigenetic function of PGx-eQTLs that interfere with GR response elements. We also applied a high-throughput enhancer assay (STARR-seq) using PGx-eQTL loci DNA sequences to “scan” for drug-dependent SNPs.

2022-11-16 | GSE189453 | GEO