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Genome-wide chromatin binding of YBX1 in nasopharyngeal carcinoma (NPC) cell line S18 (ChIP-Seq)

ABSTRACT: Genome-wide chromatin binding of YBX1 in nasopharyngeal carcinoma (NPC) cell line S18 (ChIP-Seq)

PROVIDER: PRJNA783045 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17022016_1.fastq.gz	Fastqsanger.gz
	SRR17022016_2.fastq.gz	Fastqsanger.gz
	SRR17022017_1.fastq.gz	Fastqsanger.gz
	SRR17022017_2.fastq.gz	Fastqsanger.gz

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Genome-wide chromatin binding of YBX1 in nasopharyngeal carcinoma (NPC) cell line S18 (ChIP-Seq)

Project description:The development of therapeutic resistance and metastatic dissemination takes place in 20-30% patients with nasopharyngeal carcinoma (NPC), resulting in poor survival. Hence, a better understanding of the underlying molecular mechanisms will help improve clinical outcome. We have identified a novel circRNA, circIPO7, as a promoter of metastasis and cisplatin chemoresistance in NPC cells. circIPO7 was found to bind to YBX1. Genome binding/occupancy profiling by high throughput sequencing were performed to explore the underlying molecular mechanisms.

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The RNA sequencing analysis of nasopharyngeal carcinoma (NPC) cell line S18 upon circIPO7 knockdown

Project description:The development of therapeutic resistance and metastatic dissemination takes place in 20-30% patients with nasopharyngeal carcinoma (NPC), resulting in poor survival. Hence, a better understanding of the underlying molecular mechanisms will help improve clinical outcome. We have identified a novel circRNA, circIPO7, as a promoter of metastasis and cisplatin chemoresistance in NPC cells. High-throughput RNA sequencing analysis was performed in the human nasopharyngeal carcinoma cell line S18 after transfection with control siRNA or circIPO7 siRNA.

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The RNA sequencing analysis of nasopharyngeal carcinoma (NPC) cell line S18 upon circWDR37 knockdown

Project description:Circular RNAs have been demonstrated to play significant roles in multiple biological processes, such as immune responses and tumorigenesis, suggesting it might be potential therapeutic targets. However, the function and mechanisms of circRNAs in nasopharyngeal carcinoma (NPC) metastasis remain largely unknown. In this study, we identified circWDR37 as a metastasis related circRNA. To further explore the underlying mechanism of circWDR37 promoting NPC metastasis, we performed RNA sequencing analysis of NPC cell line S18 upon circWDR37 knockdown.

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Project description:Metastasis accounts for the leading cause of treatment failure in nasopharyngeal carcinoma (NPC). However, the exact mechanisms underlying metastasis remain elusive. S18 and S26 are a pair of NPC cell lines with high and low metastasis abilities, respectively. To evaluate the expression profiles of mRNA in S18 and S26 cells will help to demonstrate genes that contribute the metastasis of NPC. We performed microarray sequencing to clarify the genes that differentially expressed in S18 and S26 cells.

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The RNA sequencing analysis of nasopharyngeal carcinoma (NPC) cell line S18 upon circIPO7 knockdown

Project description:The RNA sequencing analysis of nasopharyngeal carcinoma (NPC) cell line S18 upon circIPO7 knockdown

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The RNA sequencing analysis of nasopharyngeal carcinoma (NPC) cell line S18 upon circWDR37 knockdown

Project description:The RNA sequencing analysis of nasopharyngeal carcinoma (NPC) cell line S18 upon circWDR37 knockdown

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Project description:Increasing evidence has demonstrated a significant role for circular RNAs (circRNAs) in tumorigenesis. However, their functions in nasopharyngeal carcinoma (NPC) metastasis remain largely unknown. In this study, a model compared high and low metastatic NPC cell lines (S18 vs. S26) was constructed to determine the expression profile of circRNAs using the RNA sequencing analysis.

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Transcription profiling of human biopsies of Nasopharyngeal carcinoma (NPC) and non-malignant controls

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