Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study

ABSTRACT: Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study

PROVIDER: PRJNA783333 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17031723_1.fastq.gz	Fastqsanger.gz
	SRR17031723_2.fastq.gz	Fastqsanger.gz
	SRR17031724_1.fastq.gz	Fastqsanger.gz
	SRR17031724_2.fastq.gz	Fastqsanger.gz
	SRR17031725_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 72

Similar Datasets

Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study [10x Genomics]

Project description:These data describe single-cell RNA sequencing in cerebral organoids treated with the glucocorticoid Dexamethasone or with a vehicle control (DMSO) at 90 days in culture.

2021-12-02 | GSE189534 | GEO

Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study [Wafergen iCell8]

Project description:These data describe single-cell RNA sequencing in cerebral organoids treated with the glucocorticoid Dexamethasone or with a vehicle control (DMSO) at different culture time-points (Day-30, Day-60 and Day-90).

2021-12-02 | GSE189533 | GEO

Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study [10x Genomics]

Project description:Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study [10x Genomics]

| PRJNA783338 | ENA

Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study [Wafergen iCell8]

Project description:Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study [Wafergen iCell8]

| PRJNA783339 | ENA

Trans-omic Profiling Uncovers Molecular Controls of the Early Human Cerebral Organoid Formation

Project description:Defining molecular controls that orchestrate human brain development is essential for uncovering the complexity behind neurodevelopment and the pathogenesis of neurological disorders. Due to the difficulties in accessing embryonic and fetal brain tissues, the differentiation of human pluripotent stem cell (hPSC)-derived three-dimensional neural organoids has made it possible to recapitulate this developmental process in vitro and provide a unique opportunity to investigate human brain development and disease. To elucidate the molecular programs that drive this highly dynamic process, here, we generate a comprehensive trans-omic map of the phosphoproteome, proteome, and transcriptome of the initial stages of pluripotency and neural differentiation towards the formation of cerebral organoids. Our integrative analysis uncovers key phospho-signalling events underlying neural lineage differentiation, and their convergence on transcriptional (co-)factors and chromatin remodellers that govern downstream gene regulatory networks (GRNs). Comparative analysis with developing human and mouse embryos using these GRNs demonstrates the fidelity of our early cerebral organoids in modelling embryonic brain development. Finally, we demonstrate biochemical modulation of the AKT signalling as a key molecular switch for controlling human cerebral organoid formation. Our data provides a comprehensive resource to gain insight into the molecular controls in human embryonic brain development and also provide a guide for future development of protocols for human cerebral organoid differentiation.

2024-04-23 | PXD047423 | Pride

RGCC balances self-renewal and neuronal differentiation of neural stem cells in the developing mammalian neocortex [3D cerebral organoid]

Project description:Use cerebral organoid and mouse and mouse models to study the function of RGCC in neocortical development.

2021-07-23 | GSE157684 | GEO

Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-12-02 | GSE189535 | GEO

Single-cell ATAC-seq of human cerebral organoids

Project description:Single cell ATAC-seq (scATAC-seq) was performed at various stages of differentiation of human pluripotent stem cells to 4 month old cerebral organoids. scATAC-seq was performed on the following days of differentiation: day 0 (pluripotent stem cell), day 4 (embryoid body), day 10 (neuroectoderm), day 15 (neuroepithelium), day 30 (1 month old cerebral organoid), day 60 (2 months old cerebral organoid), and day 120 (4 months old cerebral organoid).

2019-10-16 | E-MTAB-8089 | biostudies-arrayexpress

Single-cell ATAC-seq of chimpanzee cerebral organoids

Project description:Single cell ATAC-seq (scATAC-seq) was performed at various stages of differentiation of chimpanzee induced pluripotent stem cells (iPSC) to 4 month old cerebral organoids. scATAC-seq was performed on the following days of differentiation: day 0 (pluripotent stem cell), day 4 (embryoid body), day 10 (neuroectoderm), day 15 (neuroepithelium), day 30 (1 month old cerebral organoid), day 60 (2 months old cerebral organoid), and day 120 (4 months old cerebral organoid).

2019-10-16 | E-MTAB-8043 | biostudies-arrayexpress

Trans-omic Profiling Uncovers Molecular Controls of the Early Human Cerebral Organoid Formation

2024-04-21 | GSE248901 | GEO