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DNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia

ABSTRACT: DNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia

PROVIDER: PRJNA783861 | ENA |

REPOSITORIES: ENA

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DNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia [Illumina]

Project description:Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature CD4+ T-cells caused by human T-cell lymphotropic virus type 1 (HTLV-1). Recently, it has been noted that some epigenome abnormalities including DNA methylation and tri-methylation at histone H3Lys27 (H3K27me3) contribute to malignant transformation of ATL. Hence, we investigate the combined effect of DNA demethylating agents and enhancer of zeste homolog 2 (EZH2), which catalyze H3K27me3, inhibitors in ATL. Methylaome analyse revealed that OR21 and the combination changes DNA methylation.

2023-05-03 | GSE189602 | GEO

DNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia [Affymetrix]

Project description:Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature CD4+ T-cells caused by human T-cell lymphotropic virus type 1 (HTLV-1). Recently, it has been noted that some epigenome abnormalities including DNA methylation and tri-methylation at histone H3Lys27 (H3K27me3) contribute to malignant transformation of ATL. Hence, we investigate the combined effect of DNA demethylating agents and enhancer of zeste homolog 2 (EZH2), which catalyze H3K27me3, inhibitors in ATL. Gene expression microarray analyses revealed that the combination changes gene expressions stronger than the single treatment.

2023-05-03 | GSE189603 | GEO

DNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia [Illumina]

Project description:DNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia [Illumina]

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DNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia [Affymetrix]

Project description:DNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia [Affymetrix]

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DNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-05-03 | GSE189604 | GEO

Gene expression profile of K562 and KBM5 treated with the combination of imatinib and a new demethylating agent, OR-2100

Project description:Treatment with demethylating agents in combination with tyrosine kinase inhibitors have shown improved molecular responses and survival benefits in patients with TKI-resistant or advanced-phase CML. However, little is known regarding underlying mechanism of the combination anti-tumor effect of demethylating agents and tyrosine kinase inhibitors. To analyze the combination effect, we have compared gene expression profiles among chronic myeloid leukemia (CML) cell lines (K562, KBM5) treated with imatinib (IM), a new demethylating agent, OR-2100 (OR21), and these combination therapy.

2020-09-09 | GSE157620 | GEO

DNA demethylating agents represent a therapeutic opportunity for synovial sarcoma

Project description:DNA demethylating agents represent a therapeutic opportunity for synovial sarcoma

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DNA demethylating agents represent a therapeutic opportunity for synovial sarcoma [RNA-Seq]

Project description:DNA demethylating agents represent a therapeutic opportunity for synovial sarcoma [RNA-Seq]

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DNA demethylating agents represent a therapeutic opportunity for synovial sarcoma [ChIP-Seq]

Project description:DNA demethylating agents represent a therapeutic opportunity for synovial sarcoma [ChIP-Seq]

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DNA demethylating agents represent a therapeutic opportunity for synovial sarcoma [Methylation array]

Project description:DNA demethylating agents represent a therapeutic opportunity for synovial sarcoma [Methylation array]