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Hepatic niche leads to aggressive NK-cell leukemia proliferation

ABSTRACT: Hepatic niche leads to aggressive NK-cell leukemia proliferation

PROVIDER: PRJNA784277 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17055460.fastq.gz	Fastqsanger.gz
	SRR17055461.fastq.gz	Fastqsanger.gz
	SRR17055462.fastq.gz	Fastqsanger.gz
	SRR17055463.fastq.gz	Fastqsanger.gz
	SRR17055464.fastq.gz	Fastqsanger.gz

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Hepatic niche leads to aggressive NK-cell leukemia proliferation

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Proliferation conditions promote intrinsic changes in NK Cells for an IL-10 response

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Project description:Gene expression profile of Aggressive NK cell Leukemia (ANKL) cells in liver and spleen microenvironments

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Transcriptional profiling of human hepatic NK cell subpopulations

Project description:To identify potential functional roles of liver-resident NK cells we performed RNA sequencing on FACS sorted NK cell subpopulations from liver perfusates (n=5) and healthy blood controls (n=5). Full-length transcripts were sequenced from low-input samples using a modified version of the SMART-Seq2 protocol. Hepatic CD56brightCD16- and CD56brightCD16+ samples upregulate genes associated with tissue residency.

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