Project description:Interventions: Group 1: Quantitative Expression Analysis of the proteom and gene Expression of Primary Tumor, normal tissue, and metastases
Primary outcome(s): Disease associated Proteins and Genes
Study Design: Allocation: ; Masking: ; Control: ; Assignment: ; Study design purpose: basic science
Project description:The earliest stages of mouse brain development are characterized by the differentiation of progenitor cells into neurons and glial cells, migration of immature neurons to their final destination in the brain and the initialisation of axon outgrowth and circuit formation. In different brain regions these processes occur at slightly different stages of development. As gene expression patterns greatly differ between different cell populations and brain regions, the period of early brain development is carachterized by very dynamic gene expression profiles. Therefore, we assessed gene expression in brains from mice at different stages of embryonic development (E9, E10, E11, E14 and E17) using Affymetrix GeneChIP mouse Gene 1.0 ST arrays.