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The effect of AML on platelets

ABSTRACT: The effect of AML on platelets

PROVIDER: PRJNA784696 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17069961_1.fastq.gz	Fastqsanger.gz
	SRR17069961_2.fastq.gz	Fastqsanger.gz
	SRR17069962_1.fastq.gz	Fastqsanger.gz
	SRR17069962_2.fastq.gz	Fastqsanger.gz
	SRR17069963_1.fastq.gz	Fastqsanger.gz

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The effect of AML on platelets

Project description:Early diagnosis of acute myeloid leukemia (AML) in the pre-leukemic stage remains a clinical challenge, as pre-leukemic patients show no symptoms, lacking any known morphological or numerical abnormalities in blood cells. Here, we demonstrate that platelets with structurally abnormal mitochondria emerge at the pre-leukemic phase of AML, preceding detectable changes in blood cell counts or detection of leukemic blasts in blood. We visualized frozen-hydrated platelets from mice at different time points during AML development in situ using electron cryo-tomography (cryo-ET) and identified intracellular organelles through an unbiased semi-automatic process followed by quantitative measurement. A large proportion of platelets exhibited changes in the overall shape and depletion of organelles in AML. Notably, 23% of platelets in pre-leukemic cells exhibit abnormal, round mitochondria with unfolded cristae, accompanied by a significant drop in ATP levels and altered expression of metabolism-related gene signatures. Our study demonstrates that detectable structural changes in pre-leukemic platelets may serve as a biomarker for the early diagnosis of AML.

2022-02-08 | GSE189844 | GEO

Effect of platelets on ovarian cancer cell spheroids

Project description:The effect of platelets on malignant cell growth was assessed on high-grade serous ovarian cancer cells grown in spheroids.

2021-05-13 | GSE155546 | GEO

Effect of platelets on ovarian cancer cell spheroids

Project description:Effect of platelets on ovarian cancer cell spheroids

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Effect of platelets on 3D models of ovarian cancer

Project description:A 3D multicellular model (MCM) of high grade serous ovarian cancer (HGSOC) consisting of primary human adipocytes, fibroblasts, and mesothelial cells co-cultured with HGSOC cell lines was used to examine the effect of platelets on the ovarian metastasis microenvironment.

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Effect of platelets on 3D models of ovarian cancer

Project description:Effect of platelets on 3D models of ovarian cancer

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Susree2018 - Effect of coated platelets on thrombin generation

Project description:Mathematical model of blood coagulation that simulates the effect of coated platelets on thrombin generation.

2018-08-08 | MODEL1808080001 | BioModels

Effect of iPSC-derived megakaryocytes and platelets on gene expression of HUVEC

Project description:Platelet-rich plasma (PRP), which is prepared by concentrating platelets in autologous blood, shows efficacy in chronic skin wounds via multiple growth factors. However, it exhibits heterogeneity across patients, leading to unstable therapeutic efficacy. Human induced pluripotent stem cell-derived megakaryocytes and platelets (iMPs) are capable of providing a stable supply, holding promise as materials for novel therapies. Thus, we evaluated the effect of iMPs on wound healing in vitro. iMPs specifically released FGF2 and exhibited superior enhancement on HUVEC proliferation compared to PRP. RNA-seq revealed that iMPs induce polarization to stalk cells and enhance ANGPTL4 gene expression in HUVECs. These mechanisms were suggested to provide the superior effects of iMPs.

2024-10-23 | GSE260954 | GEO

Treatment of hepatocellular carcinoma with autologous platelets encapsulating sorafenib or lenvatinib: a novel therapy exploiting tumor-platelet interactions

Project description:Hepatocellular carcinoma (HCC) activates platelets through the action of adjacent sinusoidal cells. Activated platelets bind to tumor-associated endothelial cells and release growth factors that promote tumor progression. We hypothesized that tumor inhibitors encapsulated in platelets would function as drug carriers for tumor therapy. We propose a therapeutic strategy for HCC using autologous platelets encapsulating multiple tyrosine kinase inhibitors in a rat chemically-induced HCC model. Sorafenib or lenvatinib was encapsulated in platelets isolated from tumor-bearing rats in vitro. The rats were divided into groups that received repeated intravenous injections (twice a week for 10 weeks) of the following materials: placebo, sorafenib (SOR), lenvatinib (LEN), autologous platelets, autologous platelets encapsulating sorafenib (SOR-PLT), and autologous platelets encapsulating lenvatinib (LEN-PLT). The therapeutic effect was then analyzed by ultrasonography (US) and histopathological analysis. Histopathological and US analysis demonstrated extensive tumor necrosis in the tumor tissue of SOR-PLT or LEN-PLT, but not in other experimental groups. By liquid chromatography-mass spectrometry, more abundant sorafenib was detected in tumor tissues after SOR-PLT administration than in surrounding normal tissues, but no such difference in sorafenib level was observed with SOR administration. Therefore, the use of autologous platelets encapsulating drugs might be a novel therapeutic strategy for HCC. We investigated the effect of the drug encapsulation process on the degradation of resident mRNA inherited from megakaryocytes in platelets.

2021-12-15 | GSE190863 | GEO

Effect of iPSC-derived megakaryocytes and platelets on gene expression of HUVEC

Project description:Effect of iPSC-derived megakaryocytes and platelets on gene expression of HUVEC

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Transcriptome analysis of reticulated platelets reveals a prothrombotic profile [miRNA-Seq]

Project description:To compare immature and mature platelet transcriptome Methods: reticulated or immature platelets(RPs) were defined as the platelets with the highest thiazole orange staining intensity (15% highest, RNAhigh) according to previous experiences and mature platelets were defined as the platelet with the 30% lowest thiazole orange staining intensity (RNAlow) and sorted (supplemental Figure S1D). RPs have a prothrombotic transcriptomic profile

2019-09-01 | GSE126447 | GEO

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