Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from cord blood CD34+ cells transduced with UBTF wildtype expression vectors, UBTF-TD expression vectors, or empty control vector.

ABSTRACT: Expression data from cord blood CD34+ cells transduced with UBTF wildtype expression vectors, UBTF-TD expression vectors, or empty control vector.

PROVIDER: PRJNA784970 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17076568_1.fastq.gz	Fastqsanger.gz
	SRR17076568_2.fastq.gz	Fastqsanger.gz
	SRR17076569_1.fastq.gz	Fastqsanger.gz
	SRR17076569_2.fastq.gz	Fastqsanger.gz
	SRR17076570_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 30

Similar Datasets

Expression data from cord blood CD34+ cells transduced with UBTF wildtype expression vectors, UBTF-TD expression vectors, or empty control vector.

Project description:UBTF tandem duplications (UBTF-TD) were identified frequently in relapsed pediatric acute myeloid leukemia. The purpose of this study is to investigate the functional consequence of the overexpression of UBTF-TD in normal cord blood CD34+ cells.

2022-02-22 | GSE189901 | GEO

UBTF tandem duplication AMLs are sensitive to menin inhibition

Project description:To investigate the effect of Menin inhibitor on UBTF-TD harboring AML. We characterized UBTF-TD interaction with KMT2A and Menin in different leukemia models including KMT2A-r, transduced and normal cbCD34+ cells as well as in primary AML cells with UBTF-TD mutation. We also analized gene expression pattern upon treatment with Menin inhibitor.

2023-12-01 | GSE233810 | GEO

UBTF tandem duplication acute myeloid leukemias are sensitive to menin inhibition [RNA-seq]

Project description:UBTF tandem duplications (TD) have recently emerged as a subtype-defining alteration in pediatric acute myeloid leukemia (pAML), which is characterized by HOXB gene dysregulation and a poor response to conventional chemotherapy. Here, we use protein-protein interaction studies to show that UBTF-TD maintains interactions with components of the RNA pol I complex, while also engaging with a network of unique protein interactors specific to UBTF-TD, like KMT2A. These data suggest that UBTF- TD both preserves canonical UBTF functions and demonstrates gain of function activities. Furthermore, we show that UBTF-TD and KMT2A co-localize to key genomic targets dysregulated in UBTF-TD myeloid malignancies, like HOXB gene clusters and MEIS1. Using a protein degradation system, we show that stemness, proliferation, and the HOXB molecular signature are dependent on sustained UBTF-TD localization to chromatin. Finally, we show UBTF-TD leukemias are sensitive to menin inhibition—providing a viable therapeutic strategy for children with this high-risk AML subtype.

2024-02-12 | GSE229663 | GEO

UBTF tandem duplication acute myeloid leukemias are sensitive to menin inhibition [Cut&Run]

2024-02-12 | GSE229664 | GEO

Sequencing of siRNA from soybean containing silencing vectors and empty vectors

Project description:Sequencing of siRNA from soybean containing silencing vectors and empty vectors

| PRJNA746614 | ENA

Transcriptome analysis of Con-TD and MCK-TD muscle

Project description:RNA-seq data of GTN muscle tissues of Con-TD and MCK-TD mice

2021-12-29 | GSE184646 | GEO

Antibody expression vectors

Project description:Vectors for the expression of antibodies

| PRJEB26941 | ENA

Expression data of cultured MCF10A cells transduced with MYB or MYB-NFIB expression vectors

Project description:This experiment investigates differences between control cells (empty vector) and cells with MYB or MYB-NFIB (M14N9) overexpression using MSCV vectors

2020-01-31 | GSE136095 | GEO

Empty

Project description:Empty

| PRJEB37548 | ENA

empty

Project description:empty

| PRJEB62096 | ENA