Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA sequencing data of 2102EP, VM-CUB-1, Caki-1 and DU-145 cells treated with epigenetic agent LAK31 and DMSO as solvent control

ABSTRACT: RNA sequencing data of 2102EP, VM-CUB-1, Caki-1 and DU-145 cells treated with epigenetic agent LAK31 and DMSO as solvent control

PROVIDER: PRJNA785590 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17097801.fastq.gz	Fastqsanger.gz
	SRR17097802.fastq.gz	Fastqsanger.gz
	SRR17097803.fastq.gz	Fastqsanger.gz
	SRR17097804.fastq.gz	Fastqsanger.gz
	SRR17097805.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

ATAC sequencing data of 2102EP, VM-CUB-1, Caki-1 and DU-145 cells treated with epigenetic agent LAK31 (2102EP additionally: Romidepsin, Quisinostat and MZ-1) and DMSO as solvent control

Project description:ATAC sequencing data of 2102EP, VM-CUB-1, Caki-1 and DU-145 cells treated with epigenetic agent LAK31 (2102EP additionally: Romidepsin, Quisinostat and MZ-1) and DMSO as solvent control

| PRJNA789943 | ENA

RNA sequencing data of 2102EP, VM-CUB-1, Caki-1 and DU-145 cells treated with epigenetic agent LAK31 and DMSO as solvent control

Project description:RNA sequencing data of cell lines of urological malignancies treated with the epigenetic agent LAK31 or DMSO as solvent control.

2022-09-01 | GSE190022 | GEO

ATAC sequencing data of 2102EP, VM-CUB-1, Caki-1 and DU-145 cells treated with epigenetic agent LAK31 (2102EP additionally: Romidepsin, Quisinostat and MZ-1) and DMSO as solvent control

Project description:ATAC sequencing data of cell lines of urological malignancies treated with epigenetic agents LAK31, Romidepsin, Quisinostat and MZ-1.

2022-09-01 | GSE191184 | GEO

Transcriptome profiling of human urothelial carcinoma cell lines RT-112, VM-Cub-1, SW1710, UMUC3 and a benign urothelial control HBLAK engineered to stably express HDAC5 against their vector control

Project description:Aberrant expression of histone deacetylases (HDACs) and their activity are associated with a broad range of tumor development. However, based on cell or tissue types, class IIA HDACs such as HDAC4 and HDAC5 may facilitate or inhibit cancer progression. The goal of this project is to examine the gene expression changes caused by HDAC5 expression. Here, we studied the effects of stable expression of HDAC5 (that is normally downregulated or have a weak basal expression) in four urothelial carcinoma (UC) cell lines (RT112, VM-Cub-1, SW1710, and UM-UC-3) by rRNA-depleted RNA-sequencing in comparison to their vector controls. We observed that HDAC5 expression in VM-Cub-1 triggered a drastic phenotype change from an epitheloid to a mesenchymal (i.e., epithelial-mesenchymal transition, EMT) and altogether diminished cell proliferation of the other three cell lines. Our RNA-seq data are in line with the phenotypic transformation of VM-Cub-1. In addition, we also performed a gene expression profiling of HBLAK, a spontaneously immortalized from primary human bladder epithelial cells that can be directly compared with the four UC vector cells. HBLAK vector cells only were included for RNA-seq as the cells failed to express HDAC5 after lentiviral transduction and selection.

2019-11-13 | E-MTAB-8418 | biostudies-arrayexpress

Protein expression profiling of human urothelial carcinoma cell lines RT-112, VM-Cub-1, SW1710, UMUC3 and a benign urothelial control HBLAK engineered to stably express HDAC5 against their vector control

Project description:Aberrant expression of histone deacetylases (HDACs) and their activity are associated with a broad range of tumor development. However, based on cell or tissue types, class IIA HDACs such as HDAC4 and HDAC5 may facilitate or inhibit cancer progression. The goal of this project is to examine the overall proteome changes caused by HDAC5 expression. Here, we studied the effects of stable expression of HDAC5 (that is normally downregulated or have a weak basal expression) in four urothelial carcinoma (UC) cell lines (RT112, VM-Cub-1, SW1710, and UM-UC-3) by mass spectrometry in comparison to their vector controls. We observed that HDAC5 expression in VM-Cub-1 triggered a drastic phenotype change from an epitheloid to a mesenchymal (i.e., epithelial-mesenchymal transition, EMT) and altogether diminished cell proliferation of the other three cell lines. Our mass-spec data are in line with the phenotypic transformation of VM-Cub-1. In addition, we also performed a protein expression profiling of HBLAK, a spontaneously immortalized from primary human bladder epithelial cells that can be directly compared with the four UC vector cells. HBLAK vector cells only were included for mass-spec as the cells failed to express HDAC5 after lentiviral transduction and selection.

2022-03-14 | PXD014448 | Pride

RNA sequencing data of TCam-2, 2102EP, JAR, JEG-3, NCCIT, and MPAF fibroblast cells treated with palbociclib and H2O pH3 as solvent control

Project description:RNA sequencing data of TCam-2, 2102EP, JAR, JEG-3, NCCIT, and MPAF fibroblast cells treated with palbociclib and H2O pH3 as solvent control

2021-12-15 | GSE190792 | GEO

RNA sequencing data of 2102EP cells treated with epigenetic agents Quisinostat, JIB-04, Chaetocin, MZ-1, LP99, PRT4165 and GSK343 and DMSO as solvent control

Project description:Single end 3' RNA sequencing of embryonal carcinoma cell line 2102EP treated with epigenetic agents Quisinostat, JIB-04, Chaetocin, Mz-1, LP99, PRT4165 and GSK343. DMSO was used as solvent control. Cells were treated with the epi-drugs for 16 h.

2022-01-21 | GSE189472 | GEO

Illumina Infinium MethylationEPIC BeadChip (850k) data of NCCIT / 2102EP cells deficient for CD24 and parental controls

Project description:Illumina Infinium MethylationEPIC BeadChip (850k) array analysis of DNA methylation of embryonal carcinoma cell lines NCCIT and 2102EP deficient for CD24 and parental cells. CD24 deficiency was genereted by CRISPR/Cas9 method. Three different NCCIT and 2102EP knock out clones were analyzed.

2021-08-01 | GSE176450 | GEO

RNA-seq comparative analysis of HOTAIRM1 knockdown in Caki-1 cells

Project description:RNA-seq comparative analysis of HOTAIRM1 knockdown in Caki-1 cells

2019-12-31 | GSE136604 | GEO

RNA-seq liver SHR/OlaIpcv and BN-Lx/Cub

Project description:RNA-seq liver SHR/OlaIpcv and BN-Lx/Cub to investigate the effect of genetic backgound on the transcriptome

2012-04-01 | E-MTAB-1029 | biostudies-arrayexpress