Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic and chromatin accessibility analyses of porcine alveolar macrophages exposed to Fumonisin B1

ABSTRACT: Transcriptomic and chromatin accessibility analyses of porcine alveolar macrophages exposed to Fumonisin B1

PROVIDER: PRJNA786598 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transcriptomic and chromatin accessibility analyses of porcine alveolar macrophages exposed to Fumonisin B1

Project description:Fumonisin B1 (FB1) is a mycotoxin that poses a great threat to agricultural production and human and animal health. However, the molecular mechanism underlying the cytotoxic effect of FB1 to mammals has not been systematically elucidated. Here, we utilized the porcine alveolar macrophage cell line 3D4/21 as model, and applied RNA sequencing (RNA-seq) to analyze the genome-wide transcriptional alterations of mRNA, lncRNA, circRNA and miRNA before and after exposure to FB1 in six samples. To further reveal the underlying regulatory mechanism, we applied Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) to determine the genome-wide chromatin accessibility alterations in response to FB1-induced cytotoxicity. We anticipate that this dataset will serve as valuable resource for clarifying the transcriptional and regulatory mechanism underlying the cytotoxic effect of FB1, and facilitate the identification of the key genes and signaling pathways contributing to cellular response to FB1 exposure.

2022-11-09 | GSE190291 | GEO

Transcriptomic profiles of spleen in piglets exposed to Fumonisin B1

Project description:Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium species. In mammals, this toxin causes multiple organ-specific damages. Among its multiple effects, FB1 promotes hepatotoxicity, is immunotoxic and alters the intestinal functions. Despite its inhibitory effect on de novo ceramide synthesis, the molecular mechanism of FB1 action and toxicity remain unclears. In order to explore the mechanism of FB1 toxicity, we analyzed the transcriptome of the spleen.

2019-04-15 | GSE97820 | GEO

Transcriptomic profiles of liver in piglets exposed to Fumonisin B1

2019-04-15 | GSE97818 | GEO

Transcriptomic profiles of jejunum in piglets exposed to Fumonisin B1

2019-04-15 | GSE97817 | GEO

Transcriptomic profiles of jejunal Peyer's patches in piglets exposed to Fumonisin B1

2019-04-15 | GSE97819 | GEO

Effect of Fumonisin B1 exposure on hepatic gene expression in mice fed a regular diet (CHOW) and in mice fed a High Fat Diet (HFD).

Project description:This experiment was designed to investigate the effect of Fumonisin B1 exposure on liver gene expression in male mice fed a regular diet (Chow group) and in obese mice which were fed a High fat diet (HFD). The Fumonisin B1 was provided through the drinking water.

2023-09-01 | GSE208735 | GEO

Transcriptomic profiles of jejunum, liver, spleen and jejunal Peyer's patches in piglets exposed to Fumonisin B1

2022-03-02 | GSE189198 | GEO

Obesity promotes Fumonisin B1 toxicity and induces hepatitis

Project description:Obesity promotes Fumonisin B1 toxicity and induces hepatitis

| PRJEB54776 | ENA

Differential gene expression of Arabidopsis in response to fumonisin B1 and exogenous ATP treatments

Project description:To identify genes underpinning the antagonistic effects of extracellular ATP on programmed cell death induced by fumonisin B1 (FB1), we conducted a kinetic DNA microarray experiment using samples harvested in the critical time window when exogenous ATP is known to suppress cell death. Arabidopsis cell suspension cultures were treated with FB1 at time = 0 h and exogenous ATP added at time = 40 h. Differential gene expression analysis using microarrays was performed on samples harvested at 41, 42, 44, and 48 h.

2019-12-31 | E-MTAB-3685 | biostudies-arrayexpress

b1 integrin regulates epithelial proliferation and cell shape during alveolar repair

Project description:Integrins are extracellular matrix receptors comprised of an a and b subunit that connect and mediate signaling between cells and the surrounding matrix. In organogenesis of epithelial tissues, the b1 integrin subunit regulates essential epithelial cell functions, but the role of b1 integrin in epithelial repair is poorly understood. To define the role of b1 integrin during alveolar repair, we challenged b1 integrin deficient mice with intratracheal lipopolysaccharide, resulting in increased mortality with emphysematous lungs 21 days following injury. The alveolar barrier was repopulated with an overabundance of type 2 alveolar epithelial cells, with reduced numbers of elongated alveolar type 1 cells, suggesting b1 integrin is required for type 2 to type 1 epithelial transition. Consistent with this finding, b1 deficient type 2 epithelial cells proliferated at increased rates throughout repair, lacked actin-rich cellular protrusions necessary for lateral cellular extension, and exhibited transcriptomic dysregulation of adherens junction and actin polymerization pathways. Finally, we show that b1 integrin balances actin polymerization versus stabilization through GTPase activation. Taken together, these data support a novel role for b1 integrin in re-establishing the alveolar niche after injury through modulation of type 2 epithelial cell proliferation and cytoskeletal-dependent cell shape change.

2023-06-10 | GSE205882 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data