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Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy

ABSTRACT: Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy

PROVIDER: PRJNA787216 | ENA |

REPOSITORIES: ENA

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Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy [mouse]

Project description:Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy [mouse]

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Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy [single-cell RNA-seq]

Project description:Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy [single-cell RNA-seq]

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Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy [Human bulk RNA-seq]

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Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy [mouse]

Project description:Abnormal lipid accumulation have been reported in patients with temporal lobe epilepsy (TLE) by in vivo magnetic resonance imaging (MRI). However, the role of astrocytes in the regulation of neuronal activity or lipid metabolism in epilepsy is unclear. Using single-nucleus RNA sequencing of TLE patient samples, we found lipid accumulation and lipid metabolism dysfunction mainly take place in astrocytes. Mechanistic studies revealed that apolipoprotein E (APOE) mediates lipid transfer from hyperactive neurons to astrocytes, turning them into the neurotoxic reactive phenotype

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Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-02-08 | GSE190453 | GEO

Leukocyte gene expression predicts human temporal lobe epilepsy seizure frequency

Project description:This study was performed to test the hypothesis that systemic leukocyte gene expression has prognostic value differentiating low from high seizure frequency refractory temporal lobe epilepsy (TLE). A consecutive series of sixteen patients with refractory temporal lobe epilepsy was studied. Based on a median baseline seizure frequency of 2.0 seizures per month, low versus high seizure frequency was defined as < 2 seizures/month and > 2 seizures/month, respectively.

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