Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Eggerthella lenta strain:DSM 2243_R611

ABSTRACT: Eggerthella lenta strain:DSM 2243_R611 Genome sequencing and assembly

PROVIDER: PRJNA787268 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Eggerthella lenta strain:DSM 2243_R411

Project description:Eggerthella lenta strain:DSM 2243_R411 Genome sequencing and assembly

| PRJNA787607 | ENA

Eggerthella lenta strain:DSM 2243_R211

Project description:Eggerthella lenta strain:DSM 2243_R211 Genome sequencing and assembly

| PRJNA787266 | ENA

Eggerthella lenta strain:DSM 2243_R1011

Project description:Eggerthella lenta strain:DSM 2243_R1011 Genome sequencing and assembly

| PRJNA787269 | ENA

Eggerthella lenta DSM 2243 alleviates bile acid stress response in Clostridium ramosum and Anaerostipes cacae by transformation of bile acids

Project description:Bile acids are not only crucial for the uptake of lipids, but also have widespread systematic ef-fects and shape the gut-microbiome composition. Bile acids can directly shape the gut-microbiome and can be modified by bacteria such as Eggerthella lenta which in turn plays a crucial role in host metabolism and immune response. We cultivated eight strains that represent a simplified human intestinal microbiome and inves-tigated the molecular response to bile acids, co-culturing with Eggerthella lenta and the combina-tion. We observed growth inhibition of particularly gram-positive strains during bile acid stress, which could be alleviated through co-culturing with Eggerthella lenta. The inhibition of growth was related to a decrease in membrane integrity and genotoxic effects of bile acids, which we investigated using zeta potential measurements in combination with proteomic and metabolomic analyses. Co-culturing with Eggerthella lenta alleviated stress through formation of oxidized and epimer-ized bile acids and the molecular response to co-culturing was seen to be strain specific. We also note that we could detect the recently described Microbial Bile Salt Conjugates in our cultures. This study highlights the significance of a potent bile acid modifier and how in-depth molecular analyses are required to decipher cross-communication between gut and host.

2023-02-24 | PXD035496 | Pride

Eggerthella lenta

Project description:Eggerthella lenta overview

| PRJNA48239 | ENA

Eggerthella lenta strain:C592

Project description:Eggerthella lenta strain:C592 Genome sequencing

| PRJNA384908 | ENA

Eggerthella lenta

Project description:Eggerthella lenta Raw sequence reads

| PRJNA507796 | ENA

Eggerthella lenta

Project description:Eggerthella lenta Raw sequence reads