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Jurkat T cell exposure to short hypergravity on a ground-based facility

ABSTRACT: Jurkat T cell exposure to short hypergravity on a ground-based facility

PROVIDER: PRJNA787271 | ENA |

REPOSITORIES: ENA

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Jurkat T cell exposure to short hypergravity on a ground-based facility

Project description:Jurkat T cells have been lysed after exposure to 3 or 15 minutes of 9g hypergravity in a ground-based pipette centrifuge. The RNA samples were analyzed with RNA-Seq transcriptomics.

2022-07-27 | GSE190484 | GEO

Short-term hypergravity effects on Jurkat T cells

Project description:Short-term hypergravity effects on Jurkat T cells

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Short-term hypergravity effects on Jurkat T cells

Project description:Jurkat T cells have been exposed to 9g hypergravity in a custom-built pipette centrifuge for different times (GBF2021). Additionally, Jurkat T cells have been exposed to 300g for 5 minutes in a standard benchtop centrifuge, and waited for different times until adding lysis buffer. For comparison, Jurkat T cells have been exposed to 5 minutes of 42°C.

2023-02-07 | GSE221579 | GEO

Comparative Transcriptomics on cellular reactions to short-term hypergravity [Microarray]

Project description:Jurkat T cells have been lysed after exposure to 15 minutes of 9g in a ground-based pipette centrifuge. The RNA samples were parallely analyzed with RNA-Seq and microarray transcriptomics.

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Comparative Transcriptomics on cellular reactions to short-term hypergravity

Project description:Comparative Transcriptomics on cellular reactions to short-term hypergravity

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Gene expression response to simulated gravity and hypergravity in human T cells

Project description:We investigated differentially regulated and stably expressed genes in human Jurkat T lymphocytic cells in 5min simulated microgravity and hypergravity and compared expression profiles to identify gravity-regulated and unaffected genes as well as adaptation processes.

2018-03-08 | GSE101101 | GEO

Chromosome conformation capture of Jurkat T cells during parabolic flight

Project description:Jurkat T cells have been fixated at different gravity conditions during the 4th Swiss Parabolic Flight Campaign (4SPFC). 1g inflight samples were generated by crosslinking 5 minutes prior to onset of the first parabola. Hypg samples were generated by crosslinking the samples at the end of the first hypergravity 1.8 g phase, 20 seconds after start of the parabola. µg/0g samples were generated by crosslinking the cells 20 seconds after the onset of microgravity during the first parabola. A ground control reference condition was generated by crosslinking cells that were stored inside the flight hardware but were not onboard during the flight.

2024-05-01 | GSE174291 | GEO

Comparative Transcriptomics on cellular reactions to short-term hypergravity [Microarray]

Project description:Comparative Transcriptomics on cellular reactions to short-term hypergravity [Microarray]

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Environmental and simulation facility conditions can modulate a behavioral-driven altered gravity response of Drosophila imagoes transcriptome

Project description:Genome-wide transcriptional profiling shows that reducing gravity levels in the International Space Station (ISS) causes important alterations in Drosophila gene expression. However, simulation experiments on ground, without space constraints, show weaker effects than space environment. A global and integrative analysis using the “gene expression dynamics inspector” (GEDI) self-organizing maps, reveals a subtle response of the transcriptome using different populations and microgravity and hypergravity simulation devices. These results suggest that, in addition to behavioural responses that can be detected also at the gene expression level, the transcriptome is finely tuned to normal gravity. The alteration of this constant parameter on Earth can have effects on gene expression that depends both on the environmental conditions and the ground based facility used to compensate the gravity vector. Alternative and commons effects of mechanical facilities, like the Random Positioning Machine and a centrifuge, and strong magnetic field ones, like a cryogenically cooled superconductive magnet, are discussed.

2013-06-26 | GSE33801 | GEO

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