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Signaling modality within gp130 receptor enhances tissue regeneration [WT vs Y814]

ABSTRACT: Signaling modality within gp130 receptor enhances tissue regeneration [WT vs Y814]

PROVIDER: PRJNA787635 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17189093.fastq.gz	Fastqsanger.gz
	SRR17189094.fastq.gz	Fastqsanger.gz
	SRR17189095.fastq.gz	Fastqsanger.gz
	SRR17189096.fastq.gz	Fastqsanger.gz

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Signaling modality within gp130 receptor enhances tissue regeneration

Project description:Signaling modality within gp130 receptor enhances tissue regeneration

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Signaling modality within gp130 receptor enhances tissue regeneration (bulkRNA-seq)

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Signaling modality within gp130 receptor enhances tissue regeneration [R805 treatment]

Project description:Signaling modality within gp130 receptor enhances tissue regeneration [R805 treatment]

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Signaling modality within gp130 receptor enhances tissue regeneration (Canine scRNA-seq)

Project description:Signaling modality within gp130 receptor enhances tissue regeneration (Canine scRNA-seq)

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Signaling modality within gp130 receptor enhances tissue regeneration [WT vs Y814]

Project description:Adult mammals are incapable of multi-tissue regeneration and augmentation of this potential may drastically shift current therapeutic paradigms. Here, we found that a common co-receptor of IL-6 cytokines, glycoprotein 130 (gp130), serves as a major nexus integrating various context-specific signaling inputs to either promote regenerative outcomes or aggravate disease progression. Via genetic and pharmacological experiments in vitro and in vivo, we demonstrated that a signaling tyrosine 814 (Y814) within gp130 serves as a major cellular stress sensor. Mice with constitutively inactivated Y814 (F814) exhibit regenerative, not reparative, responses after wounding in skin and anti-degenerative responses in the synovial joint. In addition, pharmacological inhibition of gp130 Y814 results in regeneration of multiple tissues in several species as well as disease modification in animal models of osteoarthritis. Our study characterizes a novel molecular mechanism that, if selectively manipulated, enhances the intrinsic regenerative capacity while preventing pathological outcomes in injury and disease.

2024-01-24 | GSE190608 | GEO

Signaling modality within gp130 receptor enhances tissue regeneration [R805 treatment]

2024-01-24 | GSE190602 | GEO

Signaling modality within gp130 receptor enhances tissue regeneration (bulkRNA-seq)

2024-01-24 | GSE168279 | GEO

Signaling modality within gp130 receptor enhances tissue regeneration (Canine scRNA-seq)

2024-01-24 | GSE168338 | GEO

Signaling modality within gp130 receptor enhances tissue regeneration

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-01-24 | GSE168395 | GEO

Transcription profiling of SNS-gp130-/- vs control mice

Project description:To analyze the effect of Glycoprotein 130 in small diameter sensory neurons, dorsal root ganglia (DRG) of conditional SNS-gp130-/- and control (gp130fl/fl) mice were collected and mRNA expression profiles were compared between the two groups. DRG samples of two littermate mice were always pooled and a total of 10 gp130fl/fl and 10 SNS-gp130-/- mice were divided into 5 groups per genotype. Expression of transcripts were analyzed using the Applied Biosystems microarray platform AB1700 (Mouse Genome Survey Microarray V2.0).

2014-08-04 | E-MTAB-2584 | biostudies-arrayexpress

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