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Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [rat]

ABSTRACT: Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [rat]

PROVIDER: PRJNA787889 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17196463.fastq.gz	Fastqsanger.gz
	SRR17196465.fastq.gz	Fastqsanger.gz
	SRR17196466.fastq.gz	Fastqsanger.gz
	SRR17196467.fastq.gz	Fastqsanger.gz
	SRR17196469.fastq.gz	Fastqsanger.gz

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Transcriptional instability prevents dispersion of functional vomeronasal receptor genes

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Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [mouse]

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Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [scRNA-seq]

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Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [rat]

Project description:Rodents perceive pheromones via vomeronasal receptors encoded by the Vr and Fpr gene superfamilies. The evolution of these latter is exceptionally dynamic. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered organization of functional V1r and Fpr genes. We also found that V1r pseudogenes are more likely to be expressed when located in a functional V1r gene cluster than when isolated. To explore the potential regulatory role played by the association of functional vomeronasal receptor genes with their clusters, we dissociated the mouse Fpr-rs3 from its native cluster via transgenesis. Singular and specific transgenic Fpr-rs3 transcription was observed in young vomeronasal neurons, but was only transient. Our data point to the existence of transcription stabilizing elements not coupled to vomeronasal gene units but rather associated with vomeronasal gene clusters, and thus explain the evolutionary conserved clustered organization of functional vomeronasal genes.

2022-10-02 | GSE190612 | GEO

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [mouse]

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Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [scRNA-seq]

2022-10-02 | GSE193024 | GEO

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-02 | GSE190613 | GEO

Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability

Project description:Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability

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Yeast EndoG prevents genome instability by degrading extranuclear DNA species

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Gene expression profiling from whole VNOs after tfap2eCre-mediated Smad4 ablation in immature basal vomeronasal neurons and OMPCre-mediated Smad4 ablation in all mature vomeronasal neurons

Project description:The vomeronasal organ (VNO) of mice contains two main types of vomeronasal sensory neurons (VSNs)- Apical and Basal. Apical VSNs express vomeronasal receptors (VRs) of the V1R family and project to the anterior accessory olfactory bulb (AOB) and VSNs in the basal portions of the epithelium express receptors of the V2R family and project to the posterior portion of the AOB. In the vomeronasal epithelium of mice we found active BMP signaling. By generating Smad4 conditional mutants we disrupted canonical TGF-b/BMP signaling in either maturing basal VSNs or in mature apical and basal VSNs.

2019-07-19 | GSE134492 | GEO

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