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Next Generation Sequencing Quantitative Analysis of altered expression of genes in LINC00665 overexpressing bladder cancer cells

ABSTRACT: Next Generation Sequencing Quantitative Analysis of altered expression of genes in LINC00665 overexpressing bladder cancer cells

PROVIDER: PRJNA787913 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17196733.fastq.gz	Fastqsanger.gz
	SRR17196734.fastq.gz	Fastqsanger.gz
	SRR17196735.fastq.gz	Fastqsanger.gz
	SRR17196736.fastq.gz	Fastqsanger.gz
	SRR17196737.fastq.gz	Fastqsanger.gz

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Project description:Bladder cancer (BCa) is one of the most commonly diagnosed urinary malignancies with an estimated yearly 550,000 new cases worldwide. Previous study revealed that DHCR24 was a crucial oncogene that widely involved in tumor initiation and progression. Yet the biological role and underlying regulatory mechanism of DHCR24 in lymph node (LN) metastasis of bladder cancer (BCa) remain unclear. Our study aims to explore the target genes of DHCR24 and the underlying mechanism in the LN metastasis of BCa.

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Project description:Bladder cancer (BCa) is one of the most commonly diagnosed urinary malignancies with an estimated yearly 550,000 new cases worldwide. Previous study revealed that LINC00665 was a crucial oncogene that widely involved in tumor initiation and progression. Yet the biological role and underlying regulatory mechanism of LINC00665 in lymph node (LN) metastasis of bladder cancer (BCa) remain unclear. Our study aims to explore the target genes of LINC00665 and the underlying mechanism in the LN metastasis of BCa.

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Next Generation Sequencing Quantitative Analysis of altered expression of genes in lncRNA LNMAT1 knockdown bladder cancer cells

Project description:Bladder cancer is one of the most common genitourinary malignancies worldwide, with approximately 429,800 new cases and 165,100 deaths annually in the world. LNMAT1 is reported to play diverse roles in the development and progression of human cancer. However, its function and underlying mechanism in bladder cancer remains unclear. The goal of this study is to identify the target genes of LNMAT1 in bladder cancer. Our results indicate that the genes regulated by LNMAT1 associated in a variety of biological functions, such as proliferation and metastasis.

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2020-11-20 | GSE156461 | GEO

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