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Mus musculus strain:C57BL6 | breed:WT

ABSTRACT: RNA-sequencing identifies the expression profile of miRNAs in the trigeminal ganglia of mice with or without trigeminal neuropathic pain

PROVIDER: PRJNA788681 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17267294.fastq.gz	Fastqsanger.gz
	SRR17267295.fastq.gz	Fastqsanger.gz
	SRR17267296.fastq.gz	Fastqsanger.gz
	SRR17267297.fastq.gz	Fastqsanger.gz
	SRR17267298.fastq.gz	Fastqsanger.gz

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Mus musculus strain:C57BL6 | breed:WT

Project description:The expression profile of lncRNAs, circRNAs, and mRNAs in the trigeminal ganglia of mice with or without trigeminal neuropathic pain

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Project description:The expression profile circRNAs in the trigeminal ganglia of mice with or without trigeminal neuropathic pain

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Project description:The cerebral cortex plays a key role in the multi-dimensional human pain experience. However, the neural mechanisms mediating pain-related cortical activity remain largely unknown, particularly in primary somatosensory cortex (S1). We therefore developed a new animal model of trigeminal neuralgia, a prototypical neuropathic pain, which allowed us to evaluate pain-related cortical dynamics with unprecedented translational relevance. Our novel model (FLIT: Foramen Lacerum Impingement of Trigeminal-nerve) displayed robust clinically relevant trigeminal neuralgia-like behaviors, including asymmetric facial grimacing, dental pain-like behaviors, anxiety-like behavior, and sexual dysfunction, capturing many features of the human pain experience. Awake FLIT mice exhibited highly synchronized spontaneous population activity in S1, due to GABAergic interneuron hypoactivity. Remarkably, clinically effective treatments including carbamazepine and trigeminal nerve root decompression abrogated S1 synchronization and alleviated trigeminal neuralgia-like behaviors. These results reveal synchronized S1 activity as a new and important cortical substrate of neuropathic pain, which can be clinically targeted to provide effective therapy.

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