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Global histone H3 lysine 9 trimethylation (H3K9me3) landscape changes in response to TGF-β1

ABSTRACT: Global histone H3 lysine 9 trimethylation (H3K9me3) landscape changes in response to TGF-β1

PROVIDER: PRJNA789664 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17253037_1.fastq.gz	Fastqsanger.gz
	SRR17253037_2.fastq.gz	Fastqsanger.gz
	SRR17253038_1.fastq.gz	Fastqsanger.gz
	SRR17253038_2.fastq.gz	Fastqsanger.gz
	SRR17253039_1.fastq.gz	Fastqsanger.gz

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Global histone H3 lysine 9 trimethylation (H3K9me3) landscape changes in response to TGF-β1

Project description:TGF-β plays an important part in the Epithelial to Mesenchymal Transition (EMT) in many malignancies. TGF-β may have pro- and anti-tumour effects in cancer cells, depending on the context and microenvironment. On the other hand, epigenetic alterations are becoming increasingly significant in a variety of biological activities. Aberrations in epigenetic processes can cause gene function to be disrupted, as well as malignant cellular change. Understanding the role of H3K9me3 in cancer survival is becoming increasingly popular. A worldwide drop in the heterochromatin mark H3 Lys9 dimethylation (H3K9me2), an increase in the euchromatin mark H3 Lys4 trimethylation (H3K9me3), and an increase in the transcriptional mark H3 Lys36 trimethylation were discovered during TGF-β induced EMT (H3K36me3). Our study focuses on locating globally H3K9me3 related regions in response to TGF-β since TGF-β and H3K9me3 play an essential role in carcinogenesis. To further understand the role and process of H3K9me3 alteration in TGF-β induced EMT, ChIP-Sequencing was done in PC-3 prostate cancer cells.

2022-08-10 | GSE191096 | GEO

Global Histone H3 lysine 4 trimethylation (H3K4me3) landscape changes in response to TGF-β1

Project description:Global Histone H3 lysine 4 trimethylation (H3K4me3) landscape changes in response to TGF-β1

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Global Histone H3 lysine 4 trimethylation (H3K4me3) landscape changes in response to TGF-β1

Project description:We performed Chromatin-Immunoprecipitation followed by Next-Generation Sequencing (ChIP-Seq) in PC-3 Cells stimulated with TGF-β1 for different duration. We used anti-H3K4me3 antibody to immunoprecipitate DNA fragment associated with H3K4me3. We found that a number of regions associated with H3K4me3 increased in a time-dependent manner upon TGF-β1 stimulation. Further the regions were classified into different Functional annotations.

2021-10-27 | GSE171058 | GEO

Histone H3 lysine 27 trimethylation of miRNA genes in HMEC and HMF

Project description:Normal cell type specific histone H3 lysine 27 trimethylation of miRNA genes. HMEC and HMF represent two distinct differentiated cell type present in mammary gland each with a distinct phenotype, a distinct epigenotype as well as distinct miRNA expression pattern. The aim of the study was to determine how epigenetic modifications including histone H3 lysine 27 trimethylation affect miRNA expression. Two cell types HMEC vs. HMF. Biological replicates: 3 pairs of HMEC-HMF of 3 distinct genotypes. Immunoprecipitation using anti-histone H3 trimethylated at lysine 27 (07-449, Millipore).

2011-04-05 | E-GEOD-28376 | biostudies-arrayexpress

Histone H3 lysine 4 trimethylation of miRNA genes in HMEC and HMF

Project description:Normal cell type specific histone H3 lysine 4 trimethylation of miRNA genes. HMEC and HMF represent two distinct differentiated cell type present in mammary gland each with a distinct phenotype, a distinct epigenotype as well as distinct miRNA expression pattern. The aim of the study was to determine how epigenetic modifications including histone H3 lysine 4 trimethylation affect miRNA expression. Two cell types HMEC vs. HMF. Biological replicates: 3 pairs of HMEC-HMF of 3 distinct genotypes. Immunoprecipitation using anti-histone H3 trimethylated at lysine 4 (05-745, Upstate).

2011-04-05 | E-GEOD-28377 | biostudies-arrayexpress

SMYD5 catalyzes histone H3 lysine 36 trimethylation at promoters

Project description:SMYD5 catalyzes histone H3 lysine 36 trimethylation at promoters

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Histone H3 lysine 4 trimethylation of miRNA genes in HMEC and HMF

2011-04-05 | GSE28377 | GEO

Histone H3 lysine 27 trimethylation of miRNA genes in HMEC and HMF

2011-04-05 | GSE28376 | GEO

Study the histone H3 lysine 9 trimethylation (H3K9me3) in adenoid cystic carcinoma cell lines (ACC) via ChIP-chip by array

Project description:Chromatin immunoprecipitation on microarrays (ChIP-chip) has been widely used to investigate the DNA binding sites for a variety of proteins such as histone and transcription factors on a genome-wide scale. The purpose of this study is to evaluate the status of histone H3 lysine 9 trimethylation in salivary gland adenoid cystic carcinoma.

2014-11-04 | E-MTAB-3053 | biostudies-arrayexpress

Localization of histone H3 and histone H3 lysine 4 trimethylation at the start of pre-meiotic S phase

Project description:ChIP-on-chip analysis of histone H3 and histone H3 lysine 4 trimethylation in cells induced to undergo synchronous meiosis after growth in nitrogen-rich conditions or after nitrogen depletion.

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