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Mechanistic insights into small-molecule inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and dSTORM

ABSTRACT: Mechanistic insights into small-molecule inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and dSTORM

PROVIDER: PRJNA791662 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17311948_1.fastq.gz	Fastqsanger.gz
	SRR17311948_2.fastq.gz	Fastqsanger.gz
	SRR17311949_1.fastq.gz	Fastqsanger.gz
	SRR17311949_2.fastq.gz	Fastqsanger.gz
	SRR17311950_1.fastq.gz	Fastqsanger.gz

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Mechanistic insights into small-molecule inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and dSTORM

Project description:The HuR small-molecule inhibitor MS-444 has been used in many cancer treatment studies, but its reproductive toxicity in females is unknown.Here, we used low-input RNA-seq and dSTORM to reveal the molecular mechanism and nanoscale organization changes by which MS-444 arrests embryonic development at the 2-cell stage.

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