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RNAseq in Sirt1 wild-type or deleted mouse T-ALLs

ABSTRACT: RNAseq in Sirt1 wild-type or deleted mouse T-ALLs

PROVIDER: PRJNA793433 | ENA |

REPOSITORIES: ENA

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RNAseq in Sirt1 wild-type or deleted mouse T-ALLs

Project description:C57BL6 mice harboring Sirt1 conditional knockout NOTCH1-HDDPEST-induced leukemias were treated with vehicle (control) or tamoxifen to induce isogenic deletion of Sirt1. Here we report the gene expression profile of leukemic blasts obtained from the spleen from control- or tamoxifen-treated leukemic mice.

2024-01-01 | GSE192842 | GEO

RNAseq in Sirt1 wild-type or conditional KO mouse T-ALLs

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RNAseq in Pten enhancer wild-type or deleted mouse T-ALLs

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RNAseq in Sirt1 wild-type or conditional KO mouse T-ALLs

Project description:C57BL6 mice harboring Sirt1 conditional knockout NOTCH1-DE-induced leukemias were treated with vehicle (control) or tamoxifen to induce isogenic deletion of Sirt1. Here we report the gene expression profile of leukemic blasts obtained from the spleen from control- or tamoxifen-treated leukemic mice.

2022-12-08 | GSE203387 | GEO

RNAseq in Pten enhancer wild-type or deleted mouse T-ALLs

Project description:C57BL6 mice harboring Pten enhancer (PE) conditional knockout NOTCH1-induced leukemias were treated with vehicle (control) or tamoxifen to induce isogenic deletion of PE. Here we report the gene expression profile of leukemic blasts obtained from the spleen from control- or tamoxifen-treated leukemic mice. GSEA analysis show a significant enrichment of Pten signature genes, consistent with a role of PE in regulating Pten expression.

2020-12-17 | GSE150894 | GEO

Genomewide gene expression analysis of murine Sirt1 wild-type or knock-out embryonic stem cells (ESCs)

Project description:Stem-cells and transformed cancer cells specifically express a polycomb repressive complex subtype, PRC4 which characteristically contains Sirt1 (Sirtuin-1), a NAD+ dependent class III histone deacetylase (HDAC) and Eed2 isoform as specific members. Analyzing the transcriptiome and methylome analysis of Sirt1 deficient murine ESCs (Sirt1-/- ESC), we demonstrate that these cells repressed specifically on some genomic imprinted and germ-line related genes. We used microarrays to characterize the programm of gene expression affected by Sirt1 in murine ESCs and identified distinct classes of down-regulated genes upon Sirt1 deficiency

2017-02-20 | GSE60500 | GEO

RNAseq in human TALL cells expressing shRNA control or against SIRT1

Project description:RNAseq in human TALL cells expressing shRNA control or against SIRT1

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Methylated CpG Island Recovery Assay (MIRA)-chip from Sirt1 wild-type (Sirt1+/+) and knock-out (Sirt1-/-) murine embryonic stem cells (ESCs)

Project description:Proper DNA-methylation is inevitable for normal development and this epigenetic program is dynamically reprogrammed especially around embryo implantation. Accordingly, embryonic stem cells (ESCs) derived from inner cell mass in pre-implantation embryo exhibit the lowest DNA methylation level compared with differentiated tissue cells to ensure their pluripotency and germ-line potency. Methylated CpG Island Recovery Assay (MIRA) coupled chip DNA methylome analysis demonstrated that Sirt1 deficiency increases the abnormal DNA methylation especially on the a subtype of imprinted and germ-line development genes.

2017-02-20 | GSE60636 | GEO

RNAseq analysis of wild type Campylobacter jejuni compared to modE deletion strain

Project description:Campylobacter jejuni is a human pathogen which causes Campylobacteriosis, one of the most widespread zoonotic enteric diseases worldwide. ModE is a transcriptional regulator that controls molybdenum uptake in many bacteria. modE (cj1507c) was deleted from C. jejuni NCTC11168 and grown alongside the parental wild type to mid-log phase in defined medium containing replete Mo, W and Se. Samples were taken for RNAseq analysis and used to compare gene expression.

2024-01-01 | E-MTAB-11503 | biostudies-arrayexpress

Proteomic profile of deleted in breast cancer 1 protein-protein interactions

Project description:Deleted in breast cancer 1 (DBC1) has emerged as an important regulator of multiple cellular processes, ranging from gene expression to cell cycle progression. DBC1 has been linked to tumorigenesis both as an inhibitor of histone deacetylases (HDAC), HDAC3 and sirtuin 1 (SIRT1), and as a transcriptional cofactor for nuclear hormone receptors. However, despite mounting interest in DBC1, relatively little is known about the range of its interacting partners and the scope of its functions. DBC1 protien interactions were studied in two cell types, T cells and HEK293 kidney cells

2015-12-17 | PXD002733 | Pride

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