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HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity

ABSTRACT: HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity

PROVIDER: PRJNA796298 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17518408_1.fastq.gz	Fastqsanger.gz
	SRR17518408_2.fastq.gz	Fastqsanger.gz
	SRR17518409_1.fastq.gz	Fastqsanger.gz
	SRR17518409_2.fastq.gz	Fastqsanger.gz
	SRR17518410_1.fastq.gz	Fastqsanger.gz

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HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [ChIP-Seq]

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HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [ATAC-Seq]

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HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [RNA-Seq]

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HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [scRNA-Seq]

Project description:HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [scRNA-Seq]

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HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [RNA-Seq]

Project description:We report mRNA seq during time course of white preadipocyte browning from WT and HMGN1 and HMGN2 double knockout (DKO) mice . Moreover, we support our finding that loss of HMGN promotes white adipocyte browning with RNA seq of WT and DKO MEFs transdifferentiation into brown-like adipocytes.

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HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [scRNA-Seq]

Project description:We report single-cell RNA seq (scRNA seq) at day 0 and day 6 of white preadipocyte browning from WT and HMGN1 and HMGN2 double knockout (DKO) mice. This supports our finding that loss of HMGN promotes white adipocyte browning with RNA seq of WT and DKO MEFs transdifferentiation into brown-like adipocytes.

2022-10-19 | GSE193462 | GEO

HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [ChIP-Seq]

Project description:We report H3K27ac ChIP seq during time course of white preadipocyte browning from WT and HMGN1 and HMGN2 double knockout (DKO) mice .

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HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-19 | GSE193463 | GEO

HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [ATAC-Seq]

Project description:We report ATAC seq of white preadipocytes from iWAT of WT and HMGN1 and HMGN2 double knockout (DKO) mice .

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SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ

Project description:The adipose tissue is a key site regulating energy metabolism. One of the contributing factors behind this is browning of white adipose tissue (WAT), however, knowledge of the intracellular determinants of browning process remains incomplete. By generating adipocyte-specific Senp2 knockout (Senp2-aKO) mice, here we showed that SENP2 negatively regulates browning by de-conjugating SUMO from C/EBPβ. Senp2-aKO mice were resistant to diet-induced obesity and insulin resistance due to increased energy expenditure and heat production. Senp2 knockout promoted beige adipocyte accumulation in inguinal WAT by upregulation of thermogenic gene expression. In addition, SENP2 knockdown promoted thermogenic adipocyte differentiation of precursor cells isolated from inguinal and epididymal WATs. Mechanistically, sumoylated C/EBPβ, a target of SENP2, suppressed expression of HOXC10, a browning inhibitor, by recruiting a transcriptional repressor DAXX. These findings indicate that a SENP2-C/EBPβ-HOXC10 axis operates for the control of beige adipogenesis in inguinal WAT.

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