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Analysis of transcriptomic transcriptomic consequences of Tyrobp deletion in a Huntington’s disease mouse model

ABSTRACT: Analysis of transcriptomic transcriptomic consequences of Tyrobp deletion in a Huntington’s disease mouse model

PROVIDER: PRJNA796618 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17592500_1.fastq.gz	Fastqsanger.gz
	SRR17592500_2.fastq.gz	Fastqsanger.gz
	SRR17592501_1.fastq.gz	Fastqsanger.gz
	SRR17592501_2.fastq.gz	Fastqsanger.gz
	SRR17592502_1.fastq.gz	Fastqsanger.gz

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Analysis of proteomic consequences of TYROBP deletion in a Huntington's disease mouse model.

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Analysis of transcriptomic transcriptomic consequences of Tyrobp deletion in a Huntington’s disease mouse model

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Project description:Purpose: The goal of this study was to determine biological consequences during liver regeneration following partial hepatectomy in mice by next-generation sequencing. A particular interest was to compare mice with either a floxed b-PDGFR allele to mice that harbored a deletion of b-PDGFR in hepatic stellate cells (HSCs), by crossing b-PDGFR fl/fl mice with transgenic GFAP-Cre mice. Methods: b-PDGFR fl/fl mice or mice with a HSC-specific deletion of b-PDGFR underwent either sham operation or 70% partial hepatectomy. Following 72 hours, livers were collected and total RNA was extracted using tizol, followed by a purification using Quiagen spin columns including an on-column DNAse digestion step. Conclusion: Our study represents a detailed analysis of hepatic transcriptome, with biologic replicates, generated by RNA-seq technology of livers following sham operation or partial hepatectomy in b-PDGFR fl/fl mice or b-PDGFRfl/fl/GRAP-Cre mice. Whole liver mRNA profiles of sham operated livers or livers collected 72hours after partial hepatectomy of beta-PDGFR fl/fl and beta-PDGFR fl/fl/GFAP-Cre (creating a hepatic stellate cell-specific deletion of b-PDGFR) mice were generated by deep sequencing, in duplicate, using Illumina HiSeq2000.

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