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Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2

ABSTRACT: Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2

PROVIDER: PRJNA797648 | ENA |

REPOSITORIES: ENA

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Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 - untreated

Project description:Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 - untreated

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Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 - CDDP therapy

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Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 - untreated

Project description:The activation status of some DNA damage repair proteins is closely related to the efficacy of CDDP chemotherapy in MIBC. In this study, we used CRISPR/cas9 gene-editing technology to construct hMSH2-deficient bladder cancer cells and confirmed that loss of hMSH2 decreased the sensitivity of bladder cancer cells to cisplatin. Transcriptome analysis was performed to find the potential genes that could be regulated by hMSH2.

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Human bladder cancer cell line high throughput sequencing

Project description:Circular RNAs (circRNAs) have been increasingly indicated to be important participants in the development and progression of various malignant tumors. In this study, we analyzed circRNA high-throughout sequencing from human bladder cancer tissues and paired adjacent normal tissues. Then we focused on the upregulated circRNAs and identified a novel circular RNA, hsa_circ_0008399 , as a new candidate circRNA derived from RBM2 gene. FISH assay has been proved that hsa_circ_0008399 mainly located in nucleus. Transcriptome analysis was performed to find the potential genes that could be regulated by hsa_circ_0008399.

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FTO regulated genes in bladder cancer cell

Project description:FTO regulated genes in bladder cancer cell

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Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-06-20 | GSE193755 | GEO

Gene Expression of human bladder cancer cell line RT112 and Gemcitabine Resistant Bladder Cancer cell line RT112-Gr

Project description:In this research, Human OneArray Microarray analysis was performed to obtain broad spectrum information about the genes differentially expressed in human bladder cancer cell line RT112 and Gemcitabine Resistant Bladder Cancer cell line RT112-Gr.

2015-04-16 | E-MTAB-3495 | biostudies-arrayexpress

High-throughput RNA sequencing on circular RNA profiles of human bladder cancer tissues and normal bladder tissues

Project description:In order to find out circular RNAs profiles in human bladder cancer tissues and normal bladder tissues, we characterized circuclar RNA transcripts by performing RNA-Seq on ribosomal RNA-depleted total RNA from three pairs of human bladder cancer tissues and paired normal bladder tissues.A computational pipeline based on the anchor alignment of unmapped reads was used to identify circular RNAs. Collectively, we identified16,535 distict circular RNAs, most of them origined from exons (88.96%), others from introns, linc RNA, intergenic region, 3’UTR and 5’UTR. Among all these circRNAs, 571 circRNAs were differentially expressed between bladder cancer tissues and normal bladder tissues, and 524 circRNAs were downregulated in bladder cancer tissues (91.2%), others were upreguluated. These significantly differential expressed circular RNA might have regulatory function in bladder cancer, and worth to be further explored.

2017-08-04 | GSE97239 | GEO

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