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Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 - untreated

ABSTRACT: Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 - untreated

PROVIDER: PRJNA797651 | ENA |

REPOSITORIES: ENA

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Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 - untreated

Project description:The activation status of some DNA damage repair proteins is closely related to the efficacy of CDDP chemotherapy in MIBC. In this study, we used CRISPR/cas9 gene-editing technology to construct hMSH2-deficient bladder cancer cells and confirmed that loss of hMSH2 decreased the sensitivity of bladder cancer cells to cisplatin. Transcriptome analysis was performed to find the potential genes that could be regulated by hMSH2.

2024-06-20 | GSE193754 | GEO

Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2

Project description:Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2

| PRJNA797648 | ENA

Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 - CDDP therapy

2024-06-20 | GSE193753 | GEO

Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 - CDDP therapy

Project description:Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 - CDDP therapy

| PRJNA797652 | ENA

Human bladder cancer cell line high throughput sequencing

Project description:Human bladder cancer cell line high throughput sequencing

| PRJNA723863 | ENA

Human bladder cancer cell line high throughput sequencing

Project description:Circular RNAs (circRNAs) have been increasingly indicated to be important participants in the development and progression of various malignant tumors. In this study, we analyzed circRNA high-throughout sequencing from human bladder cancer tissues and paired adjacent normal tissues. Then we focused on the upregulated circRNAs and identified a novel circular RNA, hsa_circ_0008399 , as a new candidate circRNA derived from RBM2 gene. FISH assay has been proved that hsa_circ_0008399 mainly located in nucleus. Transcriptome analysis was performed to find the potential genes that could be regulated by hsa_circ_0008399.

2022-04-13 | GSE173132 | GEO

FTO regulated genes in bladder cancer cell

Project description:FTO regulated genes in bladder cancer cell

| PRJNA631615 | ENA

High-throughput RNA sequencing on circular RNA profiles of human bladder cancer tissues and normal bladder tissues

Project description:In order to find out circular RNAs profiles in human bladder cancer tissues and normal bladder tissues, we characterized circuclar RNA transcripts by performing RNA-Seq on ribosomal RNA-depleted total RNA from three pairs of human bladder cancer tissues and paired normal bladder tissues.A computational pipeline based on the anchor alignment of unmapped reads was used to identify circular RNAs. Collectively, we identified16,535 distict circular RNAs, most of them origined from exons (88.96%), others from introns, linc RNA, intergenic region, 3’UTR and 5’UTR. Among all these circRNAs, 571 circRNAs were differentially expressed between bladder cancer tissues and normal bladder tissues, and 524 circRNAs were downregulated in bladder cancer tissues (91.2%), others were upreguluated. These significantly differential expressed circular RNA might have regulatory function in bladder cancer, and worth to be further explored.

2017-08-04 | GSE97239 | GEO

Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-06-20 | GSE193755 | GEO

Human bladder cancer cell line mRNA-seq

Project description:Circular RNAs (circRNAs) have been increasingly indicated to be important participants in the development and progression of various malignant tumors. Our previous studies found that hundreds of circRNAs were aberrantly expressed in bladder cancer (BC) by high-throughput sequencing and we have confirmed that the downregulated circRNAs circHIPK3, BCRC3 and circNR3C1 played inhibitory roles in BC progression. However, the role of these upregulated circRNAs remain to be clarified. In this study, we analyzed circRNA high-throughout sequencing from human tissues and focused on the upregulated circRNAs and identified a novel circular RNA, hsa_circ_0001361 (also named bladder cancer upregulated circRNA-1, BCUC-1), as a new candidate circRNA derived from FNDC3B gene. The expression levels of circRNA and miRNAs in BC tissues and cells were detected by qRT-PCR. Transwell migration, Matrigel invasion, CCK-8, EdU, cell cycle and in vivo tumor metastasis assays were preformed to evaluate the effects of circ0001361 on BC cells. Transcriptome analysis was performed to find the potential genes that could be regulated by BCUC-1. Luciferase reporter, RNA pull-down and fluorescence in situ hybridization (FISH) assays were applied to verify the interaction between BCUC-1 and miR-491-5p.

2019-09-06 | GSE136919 | GEO

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