Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Host blood-based biosignatures for subclinical TB: a prospective study of household contacts of adult pulmonary TB index cases in Southern India.

ABSTRACT: Host blood-based biosignatures for subclinical TB: a prospective study of household contacts of adult pulmonary TB index cases in Southern India.

PROVIDER: PRJNA797845 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17638900_1.fastq.gz	Fastqsanger.gz
	SRR17638900_2.fastq.gz	Fastqsanger.gz
	SRR17639000_1.fastq.gz	Fastqsanger.gz
	SRR17639000_2.fastq.gz	Fastqsanger.gz
	SRR17638901_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 288

Similar Datasets

Host blood-based biosignatures for subclinical TB: a prospective study of household contacts of adult pulmonary TB index cases in Southern India.

Project description:Identification of blood transcriptional biomarkers linked to different phases of tuberculosis. The discovery of a transcriptional signature that distinguishes subclinical TB from incipient TB at baseline could lead to tuberculosis interventions that combat the tuberculosis epidemic in the context of household contacts.

2023-01-10 | GSE193777 | GEO

Cell-specific methylation patterns in TB patients and household contacts

2015-08-25 | GSE72338 | GEO

Cell-specific gene expression patterns in TB patients and household contacts

Project description:Monocytes and granulocytes were isolated from blood of TB patients and household contacts. RNA was isolated and gene expression was measured using microarrays.

2015-08-24 | GSE70476 | GEO

Cell-specific microRNA expression patterns in TB patients and household contacts

Project description:Monocytes and granulocytes were isolated from blood of TB patients and household contacts. RNA was isolated and microRNA expression was measured using microarrays.

2015-08-24 | GSE70425 | GEO

Cell-specific methylation patterns in TB patients and household contacts

Project description:Monocytes and granulocytes were isolated from blood of TB patients and household contacts. DNA was isolated and methylation profile was measured using Illumina HumanMethylation450. House-hold contacts were matched to TB patients by gender and age. From each subject, two profiles (monocytes and granulocytes) were collected.

2015-08-25 | E-GEOD-72338 | biostudies-arrayexpress

Cell-specific microRNA expression patterns in TB patients and household contacts

Project description:Monocytes and granulocytes were isolated from blood of TB patients and household contacts. RNA was isolated and microRNA expression was measured using microarrays. House-hold contacts were matched to TB patients by gender and age. From each subject, two profiles (monocytes and granulocytes) were collected.

2015-08-24 | E-GEOD-70425 | biostudies-arrayexpress

Cell-specific gene expression patterns in TB patients and household contacts

Project description:Monocytes and granulocytes were isolated from blood of TB patients and household contacts. RNA was isolated and gene expression was measured using microarrays. House-hold contacts were matched to TB patients by gender and age. From each subject, two profiles (monocytes and granulocytes) were collected.

2015-08-24 | E-GEOD-70476 | biostudies-arrayexpress

Blood Transcriptional Profiling of a prospective HIV-negative UK Cohort of Tuberculosis Contacts

Project description:Blood transcriptional signatures may predate clinical diagnosis and detect subclinical incipient tuberculosis (TB) disease. To validate such blood signatures, close contacts of TB patients were recruited from multiple TB clinics in London. Close contacts of active TB were defined as individuals with a cumulative duration of exposure of greater than eight hours in a confined space to the index case prior to initiation of treatment. Known human immunodeficiency virus (HIV)-positive patients were excluded. At enrolment, interferon gamma release assays (IGRAs) were done using the QuantiFERON-TB Plus assay (Qiagen, Germany), and peripheral blood was collected into Tempus tubes for whole genome transcriptional profiling by RNA sequencing. Participants who progressed to active TB were identified by linkage with the national electronic TB register. Local case notes were reviewed to identify individuals who had received preventative treatment. This submission contains data from n=360 adult participants, of which n=9 progressed to TB during a median follow-up time of 1.9 years. The data were used for two publications: The first publication (Roe et al 2019) makes use of an initial subset of n=333 participants, of which n=6 progressed to TB during the median follow-up time of 346 days. In the second publication (Gupta et al 2019), we extended the dataset to n=360 participants and the median follow-up time to 1.9 years; n=3 initial non-progressors progressed to TB during this extended follow-up.

2019-08-29 | E-MTAB-6845 | biostudies-arrayexpress

NZ Household Contact Meningococci

Project description:NZ Household Contact Meningococci

| PRJEB23076 | ENA

NZ household contact meningococci

Project description:NZ household contact meningococci: RNAseq

| PRJEB23077 | ENA